KCNAB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNAB_DROME
• UniProt AC: P17970
• Protein Name: Potassium voltage-gated channel protein Shab
• Gene Name: Shab
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 985
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient..
• Protein Sequence: MVGQLQGGQAAGQQQQQQQATQQQQHSKQQQQQQQQQQQQLQLKQHQQQQQDILYQQHNEAIAIARGLQAATPADIGDNQPYYDTSGNVDWERAMGAGGAGAYGGIGIGSLPAAGGAAYHLGPANPAGLVSRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKFSEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRVLKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPEAFWWAGITMTTVGYGDICPTTALGKVIGTVCCICGVLVVALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQRMDNLEQDVPVEFECCFCTTKGLPGCHGECIPLRANSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
245	N-linked_Glycosylation	VPTHSQSNTTGALQR CCCCCCCCCCCCCCC	33.74	-
429	N-linked_Glycosylation	WELLEKPNTSFAARV HHHHCCCCCHHHHHH	60.46	-
530	N-linked_Glycosylation	FLLETNKNATDQFQD HHHHCCCCCCHHHHH	50.58	-
690	Phosphorylation	DRAKREGSIVSFHHI HHHHHHCCEEEEEEC	18.31	-
731	Phosphorylation	HPKGKRQSTPNIGRQ CCCCCCCCCCCCCCC	50.28	-
749	N-linked_Glycosylation	VQSAPGHNLSQTDGN CCCCCCCCCCCCCCC	47.50	-
756	N-linked_Glycosylation	NLSQTDGNSTEGEST CCCCCCCCCCCCCCC	48.87	-
796	Phosphorylation	NLHNRRGSSSEQDAV CCCCCCCCCCCCCCC	28.95	-
885	N-linked_Glycosylation	TAVATATNASNASNT HHHHHHHCCCCCCCC	38.62	-
888	N-linked_Glycosylation	ATATNASNASNTAPG HHHHCCCCCCCCCCC	45.00	-
914	N-linked_Glycosylation	GGGVDDDNLSQAKGL CCCCCCCCHHHCCCC	48.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
690	S	Phosphorylation	Kinase	PKA	-	Uniprot
731	S	Phosphorylation	Kinase	PKA	-	Uniprot
796	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNAB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNAB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNAS_DROME	Sh	genetic	16525044

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.