KCNAS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNAS_DROME
• UniProt AC: P08510
• Protein Name: Potassium voltage-gated channel protein Shaker
• Gene Name: Sh
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 655
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents. [PubMed: 2448636 Plays a role in the regulation of sleep need or efficiency]
• Protein Sequence: MAAVAGLYGLGEDRQHRKKQQQQQQHQKEQLEQKEEQKKIAERKLQLREQQLQRNSLDGYGSLPKLSSQDEEGGAGHGFGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAINKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELTVRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLGAQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQQQQNGFKQQQQQTQQQLQQQQSHTINASAAAATSGSGSSGLTMRHNNALAVSIETDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Sulfoxidation	-----MAAVAGLYGL -----CCHHHHHHHC	7.15	9923602
259	N-linked_Glycosylation	FKHYKVFNTTTNGTK HCCCEEEEECCCCCC	39.23	17893096
263	N-linked_Glycosylation	KVFNTTTNGTKIEED EEEEECCCCCCCCCC	54.78	17893096

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNAS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNAS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNAS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCNA_DROME	PCNA	physical	14605208
A4_DROME	Appl	genetic	10322116
CYA1_DROME	rut	genetic	14960616
KCNAE_DROME	eag	genetic	10934243
KCNAE_DROME	eag	genetic	16452147
SCNA_DROME	para	genetic	11567611
SCNA_DROME	para	genetic	2155153
MLE_DROME	mle	genetic	15728380
KINH_DROME	Khc	genetic	8770597
KCNAB_DROME	Shab	genetic	16525044
QVR_DROME	qvr	genetic	10934243
QVR_DROME	qvr	physical	20010822
QVR_DROME	qvr	physical	24613312
QVR_DROME	qvr	physical	26828958
DLG1_DROME	dlg1	physical	17666528
DLG1_DROME	dlg1	physical	25813388
DLG1_DROME	dlg1	physical	9390515

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-259 AND ASN-263, AND MASSSPECTROMETRY.
PubMed: 17893096