QVR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QVR_DROME
• UniProt AC: B5A5T4
• Protein Name: Protein quiver
• Gene Name: qvr
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 158
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability..
• Protein Sequence: MWTQRNAVGNWLLVLTAVIGFLTFIWIPQTSAECQTRSIYCYECDSWTDARCKDPFNYTALPRDQPPLMTCNGCCVKMVRHQRSPYEVVRRMCTSQLQINLFMVDHVCMMESSGNGHMCFCEEDMCNSSKNLHTNGCQLHLIPIAVAVSWLMGQLLSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	ARCKDPFNYTALPRD CCCCCCCCCCCCCCC	38.34	-
127	GPI-anchor	FCEEDMCNSSKNLHT EEHHHHCCCCCCCCC	42.55	18635795

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QVR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QVR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QVR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EWG_DROME	ewg	physical	14605208
KCNAE_DROME	eag	genetic	10934243
KCNAS_DROME	Sh	genetic	10934243

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.