DCLK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCLK_DROME
• UniProt AC: Q7PLI7
• Protein Name: Serine/threonine-protein kinase CG17528 {ECO:0000312|EMBL:EAA46000.1}
• Gene Name: CG17528
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 748
• Protein Sequence: MELEKVKINSLHCNDAVLSSLQASPSATSPQSVPSKANVVTEASIIEKTNQPHNVQEDNNYNRDCDSPESSSSEQDKELDDLRNLHSSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESVVTTNSASGSACLSNTPTADHIKKRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERYRSFERLFEDLTRLLEENVKIPGAVRTIYNLCGKKITSLDELEDGQSYVCSCNNENFKKVEYNTGSQPLSNLPLSNSRSNSHRLAKCRPSSPLKNGLLAGSSPFPACGGGTGNGSPLIASRLSDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDHVLTAITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERINTAEDFKLEAEEQRAINVIRKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSWTIGNKGNECTTYKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LEKVKINSLHCNDAV CCCCEECEEECCHHH	23.98	21082442
24	Phosphorylation	VLSSLQASPSATSPQ HHHHCCCCCCCCCCC	13.36	21082442
26	Phosphorylation	SSLQASPSATSPQSV HHCCCCCCCCCCCCC	41.50	21082442
28	Phosphorylation	LQASPSATSPQSVPS CCCCCCCCCCCCCCC	45.32	21082442
29	Phosphorylation	QASPSATSPQSVPSK CCCCCCCCCCCCCCC	22.21	21082442
44	Phosphorylation	ANVVTEASIIEKTNQ CCEEEEEEHHHHCCC	20.19	25749252
67	Phosphorylation	NYNRDCDSPESSSSE CCCCCCCCCCCCCHH	36.58	19060867
70	Phosphorylation	RDCDSPESSSSEQDK CCCCCCCCCCHHHHH	38.61	19060867
71	Phosphorylation	DCDSPESSSSEQDKE CCCCCCCCCHHHHHH	35.90	19060867
72	Phosphorylation	CDSPESSSSEQDKEL CCCCCCCCHHHHHHH	47.36	19060867
73	Phosphorylation	DSPESSSSEQDKELD CCCCCCCHHHHHHHH	41.02	19060867
87	Phosphorylation	DDLRNLHSSSLTNSV HHHHHHHHCCCCCEE	25.45	19429919
88	Phosphorylation	DLRNLHSSSLTNSVV HHHHHHHCCCCCEEE	20.72	19429919
89	Phosphorylation	LRNLHSSSLTNSVVV HHHHHHCCCCCEEEE	42.08	19429919
91	Phosphorylation	NLHSSSLTNSVVVGK HHHHCCCCCEEEEEC	27.65	19429919
93	Phosphorylation	HSSSLTNSVVVGKST HHCCCCCEEEEECCC	15.85	19429919
99	Phosphorylation	NSVVVGKSTGSLNGV CEEEEECCCCCCCCE	31.88	19429919
100	Phosphorylation	SVVVGKSTGSLNGVY EEEEECCCCCCCCEE	33.99	19429919
102	Phosphorylation	VVGKSTGSLNGVYSI EEECCCCCCCCEEEE	20.81	19429919
107	Phosphorylation	TGSLNGVYSITSVTS CCCCCCEEEEEEEEC	8.85	19429919
108	Phosphorylation	GSLNGVYSITSVTSE CCCCCEEEEEEEECC	19.58	19429919
258	Phosphorylation	SNLPLSNSRSNSHRL CCCCCCCCCCCCCCC	33.44	21082442
272	Phosphorylation	LAKCRPSSPLKNGLL CCCCCCCCCCCCCCC	36.61	27794539
296	Phosphorylation	GGGTGNGSPLIASRL CCCCCCCCCCHHHHH	22.12	21082442
339	Phosphorylation	LNKRNSPSFDHVLTA HHCCCCCCHHHHHHH	43.03	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCLK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCLK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCLK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP6A_DROME	Hsp67Ba	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-70; SER-73;SER-87; SER-88; SER-89; THR-91; SER-93 AND THR-100, AND MASSSPECTROMETRY.
PubMed: 18327897