IHOG_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IHOG_DROME
• UniProt AC: Q9VM64
• Protein Name: Interference hedgehog {ECO:0000303|PubMed:16630821}
• Gene Name: ihog
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 886
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)..
• Protein Sequence: MTLLTSSLLLFSLLTSRLEAIPVLEKSPAHPAHSAHPAHPAHPAHPAHPSPGVRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTGTAKANVSQEAAISRLRVLVRPDTLGEYRCVGWFGPLVVTSTIARLELASTSLVDAQESESPLQWRVSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEFIGTNGNLFLSNVSSESSGSYSCQATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPTVVWSSPDVVGAVKNKRSKVFGHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAELSNNFLILHSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTASVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWSLASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEFSALKQGRTQRPKTSTTEEPTLQMGDRDTTTPSHNETFNMSPMLTGTIGGGAVLILLLISTCFCVCRRRNSRSRGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNPLAQQQQQALEEKNDTDQDAPYYQRPSSYDYDPTLRRMSSSSLRRSQRTLERAGGSNGSNNGNNNNLNQSAEAGSIENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	N-linked_Glycosylation	KTGTAKANVSQEAAI ECCCCCCCCCHHHHH	33.01	19349973
215	N-linked_Glycosylation	NGNLFLSNVSSESSG CCCEEEECCCCCCCC	39.58	-
472	N-linked_Glycosylation	MYPPTPPNVTRLSDE CCCCCCCCCCCCCCC	49.33	-
563	N-linked_Glycosylation	NNDNKESNTSAKFYL CCCCCCCCCEECEEE	38.86	-
699	N-linked_Glycosylation	DTTTPSHNETFNMSP CCCCCCCCCCCCCCC	55.10	-
761	Phosphorylation	FVPLGNCSPTKQRQR CCCCCCCCCCCCCHH	39.34	23607784
763	Phosphorylation	PLGNCSPTKQRQRTR CCCCCCCCCCCHHCC	24.42	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IHOG_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IHOG_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IHOG_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IHOG_DROME	ihog	physical	17077139
PTC_DROME	ptc	physical	20048000
VEIN_DROME	vn	physical	23827685
HH_DROME	hh	physical	16630821
HH_DROME	hh	physical	20048000
HH_DROME	hh	physical	17077139
HH_DROME	hh	physical	17348690

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-108, AND MASSSPECTROMETRY.
PubMed: 19349973