NEDD4_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEDD4_DROME
• UniProt AC: Q9VVI3
• Protein Name: E3 ubiquitin-protein ligase Nedd-4
• Gene Name: Nedd4
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1007
• Subcellular Localization: Cytoplasm .
• Protein Description: Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation..
• Protein Sequence: MSARSSGLVAAAALPVPSSSSSVAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSARSSGLVAAA ---CCHHHCCCEEEE	28.60	21082442
6	Phosphorylation	--MSARSSGLVAAAA --CCHHHCCCEEEEE	30.50	21082442
39	Phosphorylation	PPRRRAASVAGQQQT CCCCCHHHHHCCHHH	16.12	27626673
46	Phosphorylation	SVAGQQQTRQEFGNG HHHCCHHHHHHHCCC	29.95	25749252
59	Phosphorylation	NGYTPRRSLAAVNDS CCCCCHHCEEECCCC	24.52	19429919
274 (in isoform 4)	Phosphorylation	-	11.07	29892262
288 (in isoform 4)	Phosphorylation	-	35.64	19429919
291 (in isoform 4)	Phosphorylation	-	41.56	19429919
294 (in isoform 4)	Phosphorylation	-	47.77	19429919
295 (in isoform 4)	Phosphorylation	-	37.78	19429919
312 (in isoform 3)	Phosphorylation	-	39.70	29892262
326 (in isoform 3)	Phosphorylation	-	37.10	19429919
329 (in isoform 3)	Phosphorylation	-	14.39	19429919
332 (in isoform 3)	Phosphorylation	-	28.72	19429919
333 (in isoform 3)	Phosphorylation	-	16.83	19429919
510	Phosphorylation	APSTRRNSEEDNAAV CCCCCCCCHHCCCCC	40.32	19429919
536	Phosphorylation	EPLPPRWSMQVAPNG CCCCCCCEEEECCCC	10.70	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEDD4_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEDD4_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEDD4_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	physical	15620649
PTC_DROME	ptc	physical	16980583
COMM_DROME	comm	physical	12165468
COMM_DROME	comm	physical	16531238

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.