dbPTM

COMM_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COMM_DROME
UniProt AC	Q24139
Protein Name	Protein commissureless 1 {ECO:0000305}
Gene Name	comm {ECO:0000312\|FlyBase:FBgn0010105}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	370
Subcellular Localization	Cytoplasmic vesicle membrane Single-pass membrane protein . Cell membrane Single-pass membrane protein .
Protein Description	Controls axon guidance across the CNS midline by preventing the delivery of Robo to the growth cone..
Protein Sequence	MISTTDYPTVETTTTAEELYAEYISAPASSMSPAAIAEHLQQNQITFEIPSAHDLRHIDALNSFNALLQRIGNAAVSYDPAPPSGWSPDGSISTEQLSKSVVLDLADLRDRSEESGESSWWSQIFGDADMHVIINYLWIGVVSSLVILSLVFILFSCYFYRKFRTWKKCNKDIRAQIHAASDSYSSHLVGCDASRLLLHQQMQHPHHRSSEAGFYQIESPPCYTIATGLPSYDEALHHQPRHFAYGMKFVYPSLAAVHHHHHCISNWEKQEPLNKLQKCKLSAAAAVEEDKADSSSSTSASASPSSSESSNLATATPAICINMPSGRQDEEVDNSDSDSAIAVAVAVAQSLQPAAPADDDCASLVVVVAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of COMM_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Nedd4	Q9VVI3	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COMM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COMM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS9_DROME	RpS9	physical	14605208
NEDD4_DROME	Nedd4	physical	17074801
RS27A_DROME	RpS27A	physical	17074801
ELAV_DROME	elav	genetic	17049509
SLIT_DROME	sli	genetic	17565966
ENA_DROME	ena	genetic	10892742
SDC_DROME	Sdc	genetic	21836636
NEDD4_DROME	Nedd4	genetic	12165468
HID_DROME	W	genetic	11832242
ABL_DROME	Abl	genetic	12973825
ERKA_DROME	rl	genetic	11832242
NEDD4_DROME	Nedd4	physical	12165468
NEDD4_DROME	Nedd4	physical	16531238

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COMM_DROME

Related Literatures of Post-Translational Modification