| UniProt ID | PICAL_DROME | |
|---|---|---|
| UniProt AC | Q9VI75 | |
| Protein Name | Phosphatidylinositol-binding clathrin assembly protein LAP | |
| Gene Name | lap | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 468 | |
| Subcellular Localization | Membrane, clathrin-coated pit . Golgi apparatus . Cytoplasmic vesicle, clathrin-coated vesicle . Colocalized with clathrin in the Golgi area. | |
| Protein Description | Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.. | |
| Protein Sequence | MTMAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIERSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYDMSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDCQSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVGEFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSKVSSPTSSGAAGASAALTNPFLSSPPAAQAGQPIVDLFGAASAQPAAAAAATKASDDLLQLGNPFADMFDASGGGAAAVGATGNAGDGTAKYDGGAGSSPFDWGATDDDGGAAQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | RLLAARHSLAGQGLA HHHHHHHHHCCCHHH | 19429919 | ||
| 287 | Phosphorylation | DLTKAPSSLLDALEQ CHHCCCHHHHHHHHH | 27794539 | ||
| 305 | Phosphorylation | TLEGRKVSAANTPTQ HHHCCCCCCCCCCCC | 25749252 | ||
| 309 | Phosphorylation | RKVSAANTPTQSSSS CCCCCCCCCCCCCCC | 25749252 | ||
| 311 | Phosphorylation | VSAANTPTQSSSSAF CCCCCCCCCCCCCCC | 27794539 | ||
| 358 | Phosphorylation | QYKSKVSSPTSSGAA HHHHHCCCCCCCCCC | 21082442 | ||
| 378 | Phosphorylation | LTNPFLSSPPAAQAG HCCCCCCCCCHHHCC | 30478224 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PICAL_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PICAL_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PICAL_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| JING_DROME | jing | genetic | 16648585 | |
| BICRD_DROME | CG32137 | genetic | 16648585 | |
| CPD1_DROME | D1 | genetic | 16648585 | |
| ATX2_DROME | Atx2 | genetic | 16648585 | |
| CNC_DROME | cnc | genetic | 16648585 | |
| ATRX_DROME | XNP | genetic | 16648585 | |
| SY65_DROME | Syt1 | physical | 24456281 | |
| DNJC5_DROME | Csp | physical | 24456281 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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