SERR_DROME - dbPTM
SERR_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SERR_DROME
UniProt AC P18168
Protein Name Protein serrate
Gene Name Ser
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1404
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues..
Protein Sequence MFRKHFRRKPATSSSLESTIESADSLGMSKKTATKRQRPRHRVPKIATLPSTIRDCRSLKSACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGSGHSLLIGVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAPELAASAASSSALHRSQPLFPPCDFERELDSSTGLKQAHKRSSQILLHKTQNSDMRKNTVGSLDSPRKDFGKRSINCKSMPPSSGDEGSDVLATTVMV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
148N-linked_GlycosylationSTGCSFGNATTKILG
CCCCCCCCCCCEECC		31.91-
192N-linked_GlycosylationLQALDMYNTSYPDAE
HHHHHHCCCCCCCHH		18.86-
243N-linked_GlycosylationQCAVTYYNTTCTTFC
EEEEEEEECCEECEE		20.64-
327N-linked_GlycosylationGCKHGSCNGSAWKCV
CCCCCCCCCCCEEEE		49.50-
408N-linked_GlycosylationTCTLKTSNRTQAQVY
EEEEECCCCCEEEEE		57.14-
448N-linked_GlycosylationRPEGQALNGSSSPGL
CCCCCCCCCCCCCCC		51.85-
554N-linked_GlycosylationATAIIGSNLSSTALL
CHHHHCCCCCHHHHH		38.43-
603PhosphorylationKEGWGGVTCAENLDD
ECCCCCEEEECCHHH		14.8522668510
628PhosphorylationCIDLVNDYRCACASG
HHHHHCCEEEHHHCC		11.4622668510
735N-linked_GlycosylationCNEGCFANVSLATSA
CCCCCCCEEEEEECC		12.03-
961N-linked_GlycosylationDPKSACQNASNTISP
CHHHHHCCCCCCCCH		45.26-
973N-linked_GlycosylationISPYTALNRSQNWLD
CCHHHHHHCCCCEEE		38.81-
1000N-linked_GlycosylationCNACVCENGTSRCTN
CCEEEECCCCCCCCC		54.65-
1026N-linked_GlycosylationDPLSKSSNLSGVCKQ
CCCCCCCCCCCCCCC		45.37-
1146N-linked_GlycosylationCDLKTGTNDTVELTV
EECCCCCCCEEEEEE		44.28-
1292PhosphorylationPLKGSTSSLRAATGM
CCCCCHHHHHHHHCC		23.2018327897
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligasemib1Q9VUX2
PMID:22199232
-KUbiquitinationE3 ubiquitin ligaseneurP29503
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SERR_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SERR_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FRIZ3_DROMEfz3genetic
10704878
NOTCH_DROMENgenetic
10588874
NOTCH_DROMENgenetic
10862754
NOTCH_DROMENgenetic
23970418
JAK_DROMEhopgenetic
16039641
SBNO_DROMEsnogenetic
9171377
EBI_DROMEebigenetic
12230979
WNTG_DROMEwggenetic
8749396
C2D1_DROMEl(2)gd1genetic
12648493
TSH_DROMEtshgenetic
15110046
APTE_DROMEapgenetic
9655817
VG_DROMEvggenetic
9501029
MAM_DROMEmamgenetic
10545243
RHOM_DROMErhogenetic
16125166
MIB_DROMEmib1genetic
15829515
FNG_DROMEfnggenetic
9247339
FNG_DROMEfnggenetic
9310337
FNG_DROMEfnggenetic
9655817
FNG_DROMEfnggenetic
9778511
RN_DROMErngenetic
11874922
DL_DROMEDlgenetic
9927593
HLES_DROMEHgenetic
8756291
CRB_DROMEcrbgenetic
20110329
NEUR_DROMEneurphysical
23045391
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SERR_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1292, AND MASSSPECTROMETRY.

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