MIB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIB_DROME
• UniProt AC: Q9VUX2
• Protein Name: E3 ubiquitin-protein ligase mind-bomb
• Gene Name: mib1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1226
• Subcellular Localization: Cytoplasm, cell cortex . Localizes at the apical cortex of cells.
• Protein Description: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur..
• Protein Sequence: MSCAATLSSAKDSTNANASGGGGGGGGGGAPTNSNTNTNTNTQSTAVGVVVSSAAGTGVGVGGGGGGGGSLPGGTTSSSSASAAGGVAAGGGGNSAAALVRRFSMEGVGARVIRGPDWKWNKQDGGEGHVGTVRNFESAEEVVVVWDNGTAANYRCAGAYDLRILDSAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERTMLEPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNGSKNLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGENGPGKGPHGFQIGDKVTVDLDLEIVQSLQHGHGGWTDGMFECLSNAGMVVGIDEDHDIVVAYNSGNRWTFNPAVLTKVSSPTTAPPEFQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEVGNTSWTYNPLAVCKVASSTASDGSCAPVIPSSERLSAILKKLFEPNVSGDATEEFVKAAANGFAARCEEYLAGAAQPSTSSASPSSGPDVNVNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDRAVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGDTPLHDAISKEHDEMLSLLLDFGADITLNNNNGFNALHHAALKGNPSAMKILLTKTNRPWIVEEKKDDGYTALHLAALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADLNIPDKDGDTPLHEALRHHTLSQLKQLQDVEGFGKLLMGLRNANNKKASASIACFLAANGADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSARARAASGSLNQSSSVNMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLHEDPPKSSASLDECLVCSDAKRDTVFKPCGHVSCCETCAPRVKKCLICRETVSSREKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCRTQIDEILSFSLCCGGSGRPEKVSVAAGAMATVGLPLPDDRFMEAAAAAACANASGHSVAMNNTVVTPVAGSSNQLNSQNNLLAAAAASSNVSNLSAAGNAMVAPSNVNNFQMDDVQKLKQQLQDIKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICRKTVEKRILLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	AALVRRFSMEGVGAR HHHHHHHCCCCCCCE	17.70	19429919
501	Phosphorylation	SCAPVIPSSERLSAI CCCCCCCCHHHHHHH	33.44	21082442
502	Phosphorylation	CAPVIPSSERLSAIL CCCCCCCHHHHHHHH	22.75	22817900
506	Phosphorylation	IPSSERLSAILKKLF CCCHHHHHHHHHHHH	21.34	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	15760269
NEUR_DROME	neur	genetic	15760269
NEUR_DROME	neur	genetic	15829515
DL_DROME	Dl	physical	15829515
DL_DROME	Dl	physical	22162135
SERR_DROME	Ser	physical	15829515

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.