KIBRA_DROME - dbPTM
KIBRA_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIBRA_DROME
UniProt AC Q9VFG8
Protein Name Protein kibra
Gene Name kibra
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1288
Subcellular Localization Cytoplasm. Apical cell membrane. Localizes at the apical cortex of epithelial cells and cytoplasmic, punctate.
Protein Description Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway..
Protein Sequence MPNLQQTASQSQHHLHPHHLRPQQQQQQHHHHHQQQQQQQHTHHQQQQQHHSDFPLPDGWDIAKDFDGKTYYIDHINKKTTWLDPRDCYTKPQTFEDCVGDELPMGWEESYDPNIGPYYINHLAQSTQLEDPRQEWKTVQEQMLSDYLSAAQDQLENKREMFDVKQQRLLWAQEEYNHLKLAASRSSLCSSSSSMSRHDPELLRADLMLARERVHQLKQELTHITNDISYTERGMNTLYSVGEKINARENGCYDIAEVHAIREEMLKVHKSLVSGEKVREELMRSLVQIKNELGRQQISEENSDLASPFDRVCVASQTDLCGSSGENLNGGARFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIEPGQLESDKDRILLIQEKEKLLNDLNSISLKSRSEEEKRVIHQTRHKLEEDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKSTKLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPFAVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASPMKYNAGADQTPQALKEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEMLSRSSSTSNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVFNDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWYNVLSSKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQAPCMELQEQMAAELLGLGPLNEPECSDDDDDDEEEELDDKQLVSDVGLMNSSSMLHAYLQNMKQEFADKETNTDRAYLPEKSRGQSQLMDDRPVKRSQTFTPSEAFSKNRYNCRLNRSDSDSAMHCGVAPHTFQRGAAERRSLRFHSKAPKSVTKLHHTHIPRTSLDLELDLQAQHSKLYFLNDQIAKLQNLKEVLQKACENKDPLVAAWAIENEEFQRLVARADPAKCPEERQLQKLLMKTAKEIHKLRKTKVPKGCPDLVSFKEKITFFTRKGLSVPELPSEFTLPEANPIEEEEEEEDENEFYNSAETAIAINTALVASSNRNKNLSEHPHRATSGAVPKIPAPVVTPAATPAATPAATPAATSAATPAATPVVSPAAQPDAKPADAPIPVASNDAEQQRFDYVVDRNYGVEV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
176PhosphorylationLLWAQEEYNHLKLAA
HHHHHHHHHHHHHHH		13.7118327897
486PhosphorylationLSTASSKSALSFTDI
CCCCCCCCCCCCCEE		36.0719429919
489PhosphorylationASSKSALSFTDIYID
CCCCCCCCCCEEEEC		26.3019429919
491PhosphorylationSKSALSFTDIYIDPF
CCCCCCCCEEEECCC		20.3619429919
537PhosphorylationPVLQQQQSAEVTLSP
HHHHHHCCEEEEECC		23.2719429919
541PhosphorylationQQQSAEVTLSPRSSL
HHCCEEEEECCCCCC		17.0219429919
543PhosphorylationQSAEVTLSPRSSLSM
CCEEEEECCCCCCCC		14.6519429919
549PhosphorylationLSPRSSLSMETPPAS
ECCCCCCCCCCCCCC		19.2729892262
552PhosphorylationRSSLSMETPPASPMK
CCCCCCCCCCCCCCC		26.4019429919
556PhosphorylationSMETPPASPMKYNAG
CCCCCCCCCCCCCCC		31.1619429919
653PhosphorylationDLPQEMLSRSSSTSN
HCCHHHHHCCCCCCC		28.8919429919
916PhosphorylationLDDKQLVSDVGLMNS
CCHHHHHHHHCCCCH		34.8622668510
923PhosphorylationSDVGLMNSSSMLHAY
HHHCCCCHHHHHHHH		15.1522668510
949PhosphorylationETNTDRAYLPEKSRG
CCCCCCCCCCCCCCC		24.5522668510
971PhosphorylationRPVKRSQTFTPSEAF
CCCCCCCCCCHHHHH		30.6221082442
990PhosphorylationYNCRLNRSDSDSAMH
CCEECCCCCCCCCCC		40.1519429919
992PhosphorylationCRLNRSDSDSAMHCG
EECCCCCCCCCCCCC		34.4119429919
994PhosphorylationLNRSDSDSAMHCGVA
CCCCCCCCCCCCCCC		31.2919429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIBRA_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIBRA_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIBRA_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MERH_DROMEMergenetic
20159598
MERH_DROMEMergenetic
20159600
MERH_DROMEMergenetic
20159599
EXPA_DROMEexgenetic
20159598
EXPA_DROMEexgenetic
20159600
EXPA_DROMEexgenetic
23733343
EXPA_DROMEexgenetic
20159599
CCNE_DROMECycEgenetic
12242236
CCNE_DROMECycEgenetic
20159600
HIPPO_DROMEhpogenetic
20159599
YAP1_DROMEykigenetic
20159599
YAP1_DROMEykigenetic
20159600
DIAP1_DROMEthgenetic
20159600
CRB_DROMEcrbgenetic
20498073
SAV_DROMEsavgenetic
20159598
SAV_DROMEsavphysical
20159598
MERH_DROMEMerphysical
20159598
MERH_DROMEMerphysical
20159599
MERH_DROMEMerphysical
20159600
EXPA_DROMEexphysical
20159598
EXPA_DROMEexphysical
20159599
HIPPO_DROMEhpophysical
20159598
APKC_DROMEaPKCphysical
26551466
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIBRA_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-992, AND MASSSPECTROMETRY.

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