dbPTM

SEPT2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEPT2_DROME
UniProt AC	P54359
Protein Name	Septin-2
Gene Name	2-Sep
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	419
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton, spindle.
Protein Description	Involved in cytokinesis..
Protein Sequence	MSVEVDFVDKKEVHLRTLKQSGHVGFDSLPDQLVNKSVQNGFVFNVMCIGETGLGKSTLMDTLFNTSFESTPSPHTLPSVKLKAHTYELQESNVRLKLTICDTVGYGDQINKDDSFKAVVDYIDAQFENYLQEELKIKRSLVTCHDSRIHICLYFICPTGHGLKSLDLVCMKKLDSKVNIIPVIAKADTISKVELQRFKAKIIQELNANGVHIYQFPTDDETVAETNTSMNSHIPFAVVGSTEFIKVGNKLIRARQYPWGTVQVENETHCDFVKLREMLIRTNMEDMREKTHTRHYELYRQKRLEQMGFSDVDSDNKPISFQQTFEAKRSNHLAELQSKEEEVRQMFVQRVKEKEAELKESEKDLHAKFEKLKRDHAEEKRKLEESRKALEEDYLDFQRRKQQLATAHHTLTLGKSKKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVEVDFVD ------CCEEEEEEC	27.30	27794539
330	Phosphorylation	QTFEAKRSNHLAELQ HHHHHHHHHHHHHHH	28.09	22817900
410	Phosphorylation	QLATAHHTLTLGKSK HHHHHHHHHCCCCCC	16.15	25749252
412	Phosphorylation	ATAHHTLTLGKSKKK HHHHHHHCCCCCCCC	34.32	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SEPT2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEPT2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEPT2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATRIP_DROME	mus304	physical	14605208
F10A1_DROME	HIP-R	physical	22036573
F10A2_DROME	HIP-R	physical	22036573
FAT_DROME	ft	physical	24114784
PNUT_DROME	pnut	physical	8636235
PNUT_DROME	pnut	physical	11884525
HRD1_DROME	sip3	physical	11884525

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEPT2_DROME

Related Literatures of Post-Translational Modification