ICCR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICCR_DROME
• UniProt AC: Q08180
• Protein Name: Irregular chiasm C-roughest protein
• Gene Name: rst
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 764
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Required for correct axonal pathway formation in the optic lobe and for programmed cell death in the developing retina..
• Protein Sequence: MLHTMQLLLLATIVGMVRSSPYTSYQNQRFAMEPQDQTAVVGARVTLPCRVINKQGTLQWTKDDFGLGTSRDLSGFERYAMVGSDEEGDYSLDIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVSVGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADRTYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANPSDVRYRWFINDEPIIGGQKTEMVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDISYAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTSTNLTFSVSNETAGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARHVSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVNDYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISEHQITKNGGVSCKLEPGDRTSNYSDLKVDISGGYVPYGDYSTHYSPPPQYLTTCSTKSNGSSTIMQNNHQNQLQLQQQQQQSHHQHHTQTTTLPMTFLTNSSGGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNGSCSNQSTTAATTTTTHVVVPSSMALSVDPRYSAIYGNPYLRSSNSSLLPPPTAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
211	N-linked_Glycosylation	KKEHHNTNFSCQAQN CCCCCCCCCCEEEEE	31.95	-
313	N-linked_Glycosylation	KTEMVIRNVTRKFHD CCCEEEEHHHHHHHH	28.52	-
393	N-linked_Glycosylation	RVVGTSTNLTFSVSN CEEEEECEEEEEECC	36.53	-
400	N-linked_Glycosylation	NLTFSVSNETAGRYY EEEEEECCCCCCEEE	48.78	-
507	N-linked_Glycosylation	AYHYGKYNCTVVNDY CCCCCCCEEEEEECC	20.61	-
549	Phosphorylation	VAFLLVLTILVVVYI HHHHHHHHHHHHHHH	12.56	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ICCR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ICCR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICCR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNA_DROME	alpha-Cat	genetic	18166433
DL_DROME	Dl	genetic	10978286
DL_DROME	Dl	genetic	11324581
ICCR_DROME	rst	physical	23827685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.