SPIR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPIR_DROME
• UniProt AC: Q9U1K1
• Protein Name: Protein spire
• Gene Name: spir {ECO:0000312|FlyBase:FBgn0003475}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1020
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Punctate spots in perinuclear region and cytopl
• Protein Description: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton..
• Protein Sequence: MTEHQAEEQADTPPTKVKATPTPTPSGKFKDAKEDAFLSTSPDSANGDAQHKLPADQLAMSSSAHPQQAGQARPLILQAFHRCSSPEQCVTLHDILDSFKAPLSEDQAWALIHQFAGLYHQVAVQAHTCAADYEAALPTGFELHFHRDGSVHFSGPDQLTPKEQLQQEQIPLPPQHDVIVDQPDHSASSSGDSSVINRAFDNSNHHHHHQHHHPPLVVSHRKIISELAEIVYTALDYNLPEDEECQVSQELENLFNFMTADETDDDCIDEGIDEGDKRWDDESEEERNDTKELEHIIETCRNHIKTTLPENHYRAVCRALVTETIELRVFLQQVLNNEAGAEKLIKASESSATTQQELAKLGFNDWARFWVQVIDELRRGVRLKKSNHERTPIEYELTPYEILMGDIRAKKYQLRKVMVNGDIPPRVKKDAHAMILEFIRSRPPLKKASDRQLGPPRMCEPSPREQLMESIRKGKELKQITPPEAPTLRERVLPSANSTLSRSRQRLIKVDFSKFQDDDLFYDENSISSSHSTAATHQHHPHFAEMHRCSQPKMPPYPFGGYMVPSQARQDCRETASLMRPRRTMEPAKQVPPPEEPSFTKDEYHKFYDTALESYDLATQCESRRASLRRHTIVGCQSNLDETHSMPPTRPESRQSDDVSKETPKRSPAEQTHPSDEGSSTSSLGPWNKSFMDKQTWMERGDDRLSVTLAEIVHIRSVMTKAELEGLPMDVRVKEDVEKRRVCFLCLRTRFSFFGPWGIQCKLCQRTVCAKCYTKMRIPSEHFRNVPLVLISPSLLSSPASSSTPSPSHHAQQAHSSSTGNIMDDQFPKSLIERLLRSESDRKTRSTVGSAPSSPKHQRSNMSTPGISVGPGASSSSAAATGQAVEALHDQATMSSSYSAAMRPSGVHQQQKQHYNNAMSRSMEGPRSLPVHSPAYRPLSNNSTLERKSRFSRGFNLFSSGSHLAQTQEQKENLRGEQVTVCNDCQGLVNEITSSVKQKRSSARNRTIQNLTLDLTPVWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	VKATPTPTPSGKFKD CCCCCCCCCCCCCCC	32.34	22817900
26	Phosphorylation	ATPTPTPSGKFKDAK CCCCCCCCCCCCCCC	58.03	22817900
39	Phosphorylation	AKEDAFLSTSPDSAN CCCCCCCCCCCCCCC	22.01	19429919
40	Phosphorylation	KEDAFLSTSPDSANG CCCCCCCCCCCCCCC	46.56	19429919
41	Phosphorylation	EDAFLSTSPDSANGD CCCCCCCCCCCCCCC	24.27	22668510
44	Phosphorylation	FLSTSPDSANGDAQH CCCCCCCCCCCCCCC	27.33	19429919
854	Phosphorylation	TVGSAPSSPKHQRSN CCCCCCCCHHHCCCC	36.59	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPIR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPIR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPIR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JNK_DROME	bsk	physical	14605208
EF1A1_DROME	Ef1alpha48D	physical	14605208
COX7A_DROME	CG9603	physical	14605208
RDX_DROME	rdx	physical	14605208
CAPU_DROME	capu	genetic	17925229
CF2_DROME	Cf2	genetic	8647437
NANOS_DROME	nos	genetic	1908748
ACT1_DROME	Act5C	physical	22106272
CAPU_DROME	capu	physical	16518391

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.