CARM1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARM1_DROME
• UniProt AC: Q9VH48
• Protein Name: Probable histone-arginine methyltransferase CARMER
• Gene Name: Art4
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 530
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling. Coordinates ecdysone-mediated expression of cell death genes..
• Protein Sequence: MSSLRPEEARKLATAASVSPLSNCQFCGVVISSIADEQKLEFTNKYKGSCTLLCSYDSQGVVLRVVSDDDRSHVLKEYMIAADTDAAQMGRRSYAVSLDADNLVLRFASEQDQQLFRKVVENVKHLRPKSVFSQRTEESSASQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNAVDFQDKIVLDVGAGSGILSFFAVQAGAAKVYAIEASNMAQYAQQLVESNNVQHKISVIPGKIEEIELPEKVDVIISEPMGYMLYNERMLETYLHARKWLKPQGKMYPTHGDLHIAPFSDESLYSEQYNKANFWYQSAFHGVDLTTLHKEGMKEYFRQPIVDTFDIRICMAKSVRHVCDFLNDKEDDLHLISIPLEFHILQTGICHGLAFWFDVEFSGSSQNVWLSTSPTAPLTHWYQVRCLLPMPIFIKQGQTLTGRVLLEANRRQSYDVTIDLHIEGTLISSSNTLDLKNPYFRYTGAPVQAPPGTSTQSPSEQYWTQVDTQGSRNSSSMLNGGISVNGIGEGMDITHGLMHPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	RKLATAASVSPLSNC HHHHHHHCCCCCCCC	22.21	21082442
501	Asymmetric dimethylarginine	QVDTQGSRNSSSMLN EECCCCCCCCCCHHC	54.60	-
501	Methylation	QVDTQGSRNSSSMLN EECCCCCCCCCCHHC	54.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARM1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARM1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARM1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RU1C_DROME	snRNP-U1-C	physical	14605208
RSMB_DROME	SmB	physical	14705965
PABP_DROME	pAbp	physical	14705965
SQD_DROME	sqd	physical	14705965
VASA2_DROME	vas	physical	14705965
VASA1_DROME	vas	physical	14705965

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.