dbPTM

VASA2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VASA2_DROME
UniProt AC	B6JUP5
Protein Name	Sister chromatid cohesion protein solo {ECO:0000303\|PubMed:20142422}
Gene Name	solo {ECO:0000303\|PubMed:20142422, ECO:0000312\|FlyBase:FBgn0283440}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1031
Subcellular Localization	Chromosome, centromere . Colocalizes with SMC1 to meiotic centromeres from early prophase I until both proteins disappear at anaphase II. Ord is required for stable centromere localization.
Protein Description	Isoform solo and SMC1 function as partners in mediating sister chromatid and centromere cohesion in meiosis. Not required for sister chromatid arm cohesion or for mitotic chromatid segregation..
Protein Sequence	MSDDWDDEPIVDTRGARGGDWSDDEDTAKSFSGEAEGDGVGGSGGEGGGYQGGNRDVFGRIGGGRGGGAGGYRGGNRDGGGFHGGRREGERDFRGGEGGFRGGQGGSRGGQGGSRGGQGGFRGGEGGFRGRLYENEDAKELPPIPSSCDKDEVGAFIDQLDLSKYTTSLALIRKLRDYLLTAFKALVNQAWASLEKLAQEKRAQKAHQIRETTDMMNRLMEDMGRLIREGEHEEANGIGMGFQSIDADCRADLSQWRNLQQVVMPQSSEIRDGQTNRTSGTEGGRSGGLTDGDDLTEIQSAAYAVYHQVLDRGYQTGRRLYDDNQGALREDSIPTEDREHPENNQVDGSTYGVTRFLHWLSENFVTRHEIRAVRFGSPHMVFQSYDWPESPKQHISTVHQKGIFYSQPLIRTRIIATVASEPNNSSSGQLSSMVNLARHQRSQNQETPDGIYVSRYNATGDEETPCSATGVPGRVVALRASSTPNEHRSDPGLSFIPNLTYEDGTIPSLAAGGAASTPLAPSLPAEHSLGLEMDSNTLVVPADADETRLVGHPGSTVVRSRLGGPPASTPLLSFRPRLPVIDEEHHLRFTRVSRELQMSVAFPPEETTLSEQREWGSIFRPRDEMVNYAEGPPPRQTQRARRRSRTRRRRNRIASAASPQLTPERIVRREEAFQSSRHIAATFMSSLLQNAAGEVTTSSGLAVTRSVKEITTSVHITRNVLQEEVPPTTEATTTSLEVAQATGYSDSGACMQSAAFSQDLPVVAPLEISGNASSDQASFDQALALLPPINSTPIGQHPIAVFGPKTEIEIKPQKMDISNMMNTSVPPMPMEVDEVPLEVSNTLANMSDHAYVTDIQILPSLQLNSLNLVSTNITDNAVNIAPSTSTNDLQTPSDRRTSMQNQLYRVSMNDLAYISQHANVVRLMVDRQEELGAQVSSLGPFKENSQGALNFSTMPAVKVYDPRIIQNIQKDKMRVVHGLFGALIRQSQVDMHNAPFIRNRKDALMAYRFLLELKTANIISLSSDGRFFGLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	GARGGDWSDDEDTAK CCCCCCCCCCHHHHH	39.67	28490779
27	Phosphorylation	DWSDDEDTAKSFSGE CCCCCHHHHHHCCCC	33.66	17189197
43	Phosphorylation	EGDGVGGSGGEGGGY CCCCCCCCCCCCCCC	37.38	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VASA2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VASA2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VASA2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RS27A_DROME	RpS27A	physical	14588248

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VASA2_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND THR-27, AND MASSSPECTROMETRY.	18327897 [Abstract]