dbPTM

ERO1L_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ERO1L_DROME
UniProt AC	Q9V3A6
Protein Name	Ero1-like protein
Gene Name	Ero1L
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	483
Subcellular Localization	Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side.
Protein Description	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity)..
Protein Sequence	MTTRTVQRNLWASAAVVLVLLLLWTDTTGGYFAAIDETETSKNCFCELEGSINDCSCDVDTVDHFNNMKIYPRLQSLLVKNFFRFYKVNLRQECPFWPDDSRCAMRFCQVENCEEQAIPQGIKDKGEHKEKAAFKYTREAQVGGSACSDGEDFDSSLGFLDTSISDQAHREFELWAKHDEAEEDFCIVDDHEEGSQYVDLLLNPERYTGYKGESAHRIWKSIYLENCFGGNNETANKFSNYVPHLDLRNVCLEQRAFYRIISGLHSSINIHLCSKYLLSESKDFLDPQGIWGPNVKEFKRRFSPETTSGEGPHWLRNLYFIYLIELRALAKAAPYLRREDYYTGIAEEDDEVKLAINDMLSVIENFQSHFDENALFSNGIASIKFKHDYKEKFRNISRIMSCVGCDKCKLWGKLQTQGLGTALKILYSEKLNLATESGLWDKPHIEADPIFRLSRTEIVALFNAFGRLSNSIYEMENFRCVLR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
232	N-linked_Glycosylation	ENCFGGNNETANKFS HCCCCCCHHHHHHHH	51.80	-
395	N-linked_Glycosylation	DYKEKFRNISRIMSC CHHHHHCCHHHHHHH	39.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ERO1L_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ERO1L_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ERO1L_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ERO1L_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ERO1L_DROME

Related Literatures of Post-Translational Modification