dbPTM

OMB_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OMB_DROME
UniProt AC	Q24432
Protein Name	Optomotor-blind protein
Gene Name	bi
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	972
Subcellular Localization	Nucleus .
Protein Description	Essential protein that may function as a transcription regulator. Vital for pupal development. Required for proper development of the optic lobes and wings, and abdominal pigmentation..
Protein Sequence	MRYDVQELLLHQSAEDPFARFANGMAYHPFLQLTQRPTDFSVSSLLTAGSNNNNSGNTNSGNNNSNSNNNTNSNTNNTNNLVAVSPTGGGAQLSPQSNHSSSNTTTTSNTNNSSSNNNNNNSTHNNNNNHTNNNNNNNNNTSQKQGHHLSTTEEPPSPAGTPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHPSHHPTAAHHSPSTGAAAPPAGPTGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSAALAAWFNHLAGAGAGASEHAAAAAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGSLGSAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPTRPISMSPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAAAAALQLAEEAAQHHHHTQAHHQQQQHQSHHQQQHHQQPAQPHPHHQTHLHSHHGATTGGTDQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
301	Phosphorylation	AEDVVLASAVAHQLH HHHHHHHHHHHHHHC	21.08	22817900
887	Phosphorylation	AQSQHSPSELKSMEK HHCCCCHHHHHHHHH	59.58	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OMB_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OMB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OMB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS29_DROME	RpS29	physical	14605208
HEP_DROME	hep	genetic	10408443
DECA_DROME	dpp	genetic	8599120
WNTG_DROME	wg	genetic	10408443
MK14B_DROME	p38b	genetic	10022918
APTE_DROME	ap	genetic	8599120
CI_DROME	ci	genetic	15708556

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OMB_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887, AND MASSSPECTROMETRY.	18327897 [Abstract]