LARK_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LARK_DROME
• UniProt AC: Q94901
• Protein Name: RNA-binding protein lark
• Gene Name: lark
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 352
• Subcellular Localization: Cytoplasm . Nucleus . The precise location within neurons varies according to the type of neuron, being cytoplasmic in CCAP neurons and nuclear in the CNS.
• Protein Description: Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in it's development..
• Protein Sequence: MPGAGTFKLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECPRLYGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYERRYQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPHGYEDFSRDAFDERMISSRGMRGPSPPGRRYAPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	SKECPRLYGSAGGGR CCCCCCCCCCCCCCC	15.43	21082442
189	Phosphorylation	ECPRLYGSAGGGREP CCCCCCCCCCCCCCC	15.35	21082442
198	Phosphorylation	GGGREPPSPLSAGGY CCCCCCCCCCCCCCC	49.54	19429919
201	Phosphorylation	REPPSPLSAGGYRDR CCCCCCCCCCCCCCC	28.40	19429919
236	Phosphorylation	IMDGFRDYDYYDRRF HHHCCCCCCHHHHCC	11.11	19429919
250	Phosphorylation	FEDSRDLYERRYQTS CCCHHHHHHHHHHHH	16.22	18281928
282	Phosphorylation	LPPTLSGSLRSCSVS CCCCCCCCCCCCEEC	19.75	21082442
287	Phosphorylation	SGSLRSCSVSRGYDT CCCCCCCEECCCCCC	25.11	27626673
294	Phosphorylation	SVSRGYDTMFSRRSP EECCCCCCCCCCCCC	16.19	22668510
297	Phosphorylation	RGYDTMFSRRSPPPP CCCCCCCCCCCCCCC	18.89	22668510
300	Phosphorylation	DTMFSRRSPPPPRSS CCCCCCCCCCCCCCC	40.42	19429919
313	Phosphorylation	SSNGMSRYGSPTPHG CCCCCCCCCCCCCCC	18.04	19429919
315	Phosphorylation	NGMSRYGSPTPHGYE CCCCCCCCCCCCCCC	19.37	19429919
317	Phosphorylation	MSRYGSPTPHGYEDF CCCCCCCCCCCCCCC	29.61	19429919
325	Phosphorylation	PHGYEDFSRDAFDER CCCCCCCCHHHHCHH	41.39	19429919
343	Phosphorylation	SRGMRGPSPPGRRYA CCCCCCCCCCCCCCC	46.69	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LARK_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LARK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LARK_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_DROME	betaTub56D	physical	14605208
DCO_DROME	dco	genetic	25211129
NIPB_DROME	Nipped-B	physical	27662615
RHOM_DROME	rho	physical	27662615
DCO_DROME	dco	physical	25211129
CUT_DROME	ct	physical	27662615

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198; SER-201; SER-315AND SER-325, AND MASS SPECTROMETRY.
PubMed: 18327897