FAS3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAS3_DROME
• UniProt AC: P15278
• Protein Name: Fasciclin-3
• Gene Name: Fas3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 508
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system..
• Protein Sequence: MSRIVFICLAAILTDALTWAQVNVEPNTALLNEGDRTELLCRYGRSINYCRIEIPGEQKVLNLSPEWSKTPGFTYFGAGLTAGQCGVSIERVKASNNGQVKCSLGVEGEELSGTIDLVVALRPQQPIIELLSRPNREGYFNEGTEFRARCSVRDGRPPANISWYIDNMPANKRTTPLEVMSSTNDNVELSTSVQEIQWHLSPEDSNRKLVCRSHHQTDRESVPPQEAAYIINVRYAPVHQPDAAVYGLYLEHTAIVNITIRASPQPKIEWTIDGAIVGQGRTDGRYSAYEPQYLGNDEYNVTLAIAGLTLEDTTKIYNLRASNELGLTDYQVRISSSSKPPSSSLDVAAIVGIVVAVAVLVLVVLLIVFARATGRWCFGGKSIKTPTNETSDTESADIKATSTATATTTMGGVGVSAEEEETVNEQESPQEQQQQQQKKAKRLPAFAAAILRRFNEKDSRKYKDNQESLNIVEGSVQEIPATNNAIDGNDNEPKAIVWQSTSPVWTFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Pyrrolidone_carboxylic_acid	TDALTWAQVNVEPNT HHHCHHHHCCCCCCC	20.91	-
21	Pyrrolidone_carboxylic_acid	TDALTWAQVNVEPNT HHHCHHHHCCCCCCC	20.91	2509076
21	Pyrrolidone_carboxylic_acid	TDALTWAQVNVEPNT HHHCHHHHCCCCCCC	20.91	2509076
160	N-linked_Glycosylation	RDGRPPANISWYIDN CCCCCCCCEEEEECC	34.30	-
257	N-linked_Glycosylation	LEHTAIVNITIRASP EEEEEEEEEEEECCC	21.41	-
300	N-linked_Glycosylation	YLGNDEYNVTLAIAG CCCCCCCEEEEEEEC	20.46	-
382	Phosphorylation	RWCFGGKSIKTPTNE CCCCCCEECCCCCCC	32.37	-
391	Phosphorylation	KTPTNETSDTESADI CCCCCCCCCCCCCCC	36.03	27794539
395	Phosphorylation	NETSDTESADIKATS CCCCCCCCCCCEEEC	33.08	27794539
459	Phosphorylation	RRFNEKDSRKYKDNQ HHHCHHCCCCCCCCH	41.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAS3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAS3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAS3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS27A_DROME	RpS27A	physical	24292889
RG68F_DROME	RhoGAP68F	genetic	25617722
TOLL_DROME	Tl	genetic	10366624
FAS3_DROME	Fas3	physical	23827685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.