| UniProt ID | CBPD_DROME | |
|---|---|---|
| UniProt AC | P42787 | |
| Protein Name | Carboxypeptidase D | |
| Gene Name | svr | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1406 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | Required for the proper melanization and sclerotization of the cuticle.. | |
| Protein Sequence | MPTLGLLFASIGIAVLAMGVPHCRGYTIKEDESFLQQPHYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGDETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQSHVHQLRAQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKLAPVETNFDGNFRKVKVERSEPPQKLKKQFNGFLTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYVANMHGNEVVGKELLLILTKYMLERYGNDDRITKLVNGTRMHFLYSMNPDGYEISIEGDRTGGVGRANAHGIDLNRNFPDQYGTDRFNKVTEPEVAAVMNWTLSLPFVLSANLHGGSLVANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMYLGQPCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREPLLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYAPLRMEVEVPDVHPFEMRMDITLMPDDPQHWASANDFRIIENVVNTRYHTNPQVRARLAELENQNGQIASFGYADSEFGTIFNYLKMTSDIGEPEEHKYKLLVVSSLYDTTAPLGREILLNLIRHLVEGFKLQDTSVVELLKRSVIYFLPQTSKFQNVFDMYNSNTSICDPVLGDELAERILGPETDQAKDVFLQFLRSERFDLMLTFGAGNSDLNYPKGDSVLVKFAHRMQRTEFNYSPLQCPPSATRQLHRETTERLTNMMYRIYNLPVYTLGISCCRMPHQKKIASVWRKNIDKIKNFLALVKTGVSGLVQNDKGQPLREAYVRLLEHDRIINVTKNVARFQLMLPHGLYGLEVTAPNYESQMIKVDVEDGRVTELGIIRMHPFTLIRGVVLELPNNDNRATTSIAGVVLDESNHPVRNAKVSVVGQTQLRNFTGSMGQYRISAVPLGTITLKVEAPRHLEATRQMHLIQGGLATENVVFHLKVNEHVFGLPRFLFILCASVLIIVGVIVCVLCAQFWFYRRHRGDKPYYNFSLLPQRGKEQFGLEDDDGGDDGETELFRSPIKRELSQRAHLVNNQTNYSFIIQAA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 133 | N-linked_Glycosylation | SDLGQLVNSTDIYLV HHHHHHHCCCCEEEE | 48.02 | - | |
| 269 | N-linked_Glycosylation | MRKGNNCNDSFSGGI CCCCCCCCCCCCCCC | 50.51 | - | |
| 384 | Phosphorylation | LLTPGLYSVHASAFG HCCCCCEEEEHHHCC | 16.69 | 22668510 | |
| 458 | N-linked_Glycosylation | PTKYEHHNFTAMESY CCCCCCCCHHHHHHH | 37.56 | - | |
| 549 | N-linked_Glycosylation | DRITKLVNGTRMHFL CHHHHHCCCCEEEEE | 57.46 | - | |
| 612 | N-linked_Glycosylation | PEVAAVMNWTLSLPF HHHHHHHEEEECCCE | 23.21 | - | |
| 652 | N-linked_Glycosylation | DPFMRLRNSSINGRK CHHHHHHCCCCCCCC | 44.71 | - | |
| 787 | N-linked_Glycosylation | VVRLDGANHSTYSQV EEEECCCCCCCHHHH | 34.86 | - | |
| 808 | N-linked_Glycosylation | LALPGRHNLTVLGDN EECCCCCCEEEECCC | 35.73 | - | |
| 981 | N-linked_Glycosylation | VFDMYNSNTSICDPV HHHHHCCCCCCCCHH | 33.92 | - | |
| 1152 | N-linked_Glycosylation | LEHDRIINVTKNVAR HHHCCEEEECCCCEE | 32.79 | - | |
| 1233 (in isoform 8) | Phosphorylation | - | 41.24 | 22817900 | |
| 1251 | N-linked_Glycosylation | VGQTQLRNFTGSMGQ ECCCEEECCCCCCCE | 47.64 | 17893096 | |
| 1256 (in isoform 8) | Phosphorylation | - | 4.03 | 22817900 | |
| 1276 (in isoform 8) | Phosphorylation | - | 15.66 | 22817900 | |
| 1378 (in isoform 4) | Phosphorylation | - | 6.22 | 22817900 | |
| 1380 (in isoform 5) | Phosphorylation | - | 24.52 | 22817900 | |
| 1380 | Phosphorylation | GETELFRSPIKRELS CCCHHCCCHHHHHHH | 24.52 | 12393882 | |
| 1401 (in isoform 4) | Phosphorylation | - | 3.94 | 22817900 | |
| 1403 (in isoform 5) | Phosphorylation | - | 1.83 | 22817900 | |
| 1421 (in isoform 4) | Phosphorylation | - | 22817900 | ||
| 1423 (in isoform 5) | Phosphorylation | - | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CBPD_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CBPD_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CBPD_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster."; Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.; Glycobiology 17:1388-1403(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1251, AND MASSSPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1380, AND MASSSPECTROMETRY. | |
