| UniProt ID | ACES_DROME | |
|---|---|---|
| UniProt AC | P07140 | |
| Protein Name | Acetylcholinesterase | |
| Gene Name | Ace | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 649 | |
| Subcellular Localization |
Cell junction, synapse. Cell membrane Lipid-anchor, GPI-anchor. Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor. |
|
| Protein Description | Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.. | |
| Protein Sequence | MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSASISPRLQLLGIAALIYICAALRTKRVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | N-linked_Glycosylation | EIWNPNTNVSEDCLY CCCCCCCCCCCCCEE | 41.79 | 1730712 | |
| 174 | N-linked_Glycosylation | IHNGNPQNTTNGLPI CCCCCCCCCCCCCCE | 50.56 | 1730712 | |
| 331 | N-linked_Glycosylation | LINDCNCNASMLKTN HHHHCCCCHHHHCCC | 22.51 | 1730712 | |
| 531 | N-linked_Glycosylation | YFFGQPLNNSLQYRP EEECCCCCCCCCCCC | 42.60 | 1730712 | |
| 619 | GPI-anchor | AGTCDGDSGSASISP ECCCCCCCCCCCCCH | 39.93 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ACES_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ACES_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ACES_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PDE4B_DROME | dnc | genetic | 14507965 | |
| PDE4E_DROME | dnc | genetic | 14507965 | |
| PDE4C_DROME | dnc | genetic | 14507965 | |
| PDE4A_DROME | dnc | genetic | 14507965 | |
| KAPR1_DROME | Pka-R1 | genetic | 14507965 | |
| APLP_DROME | Rfabg | physical | 15875013 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Post-translational modifications of Drosophila acetylcholinesterase.In vitro mutagenesis and expression in Xenopus oocytes."; Mutero A., Fournier D.; J. Biol. Chem. 267:1695-1700(1992). Cited for: GLYCOSYLATION AT ASN-126; ASN-174; ASN-331 AND ASN-531, ABSENCE OFGYCOSYLATION AT ASN-569, INTERCHAIN AT CYS-615, AND MUTAGENESIS OFASN-126; ASN-174; CYS-328; ASN-331; ASN-531; ASN-569 AND CYS-615. | |
