dbPTM

PLU_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLU_DROME
UniProt AC	P42570
Protein Name	DNA replication inhibitor plutonium
Gene Name	plu
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	174
Subcellular Localization
Protein Description	Inhibits DNA replication early in developments. May bind and block the action of a replication or initiation factor..
Protein Sequence	MGEINALSCVGQDDVVSLRIVCTMARDGKQHNLEDVDMYGNTALLKACYLGRFECARTLLEFGANIFAMNYFGQNALTLATYAGHLTLVKELLRRRSYKDFNLSSMIPALCVATLQKHSALVAYFTQLDSRGVQETQTVHGLGVAELRGMIKAAGRLDKRNVRSPPTFISNRLR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
164	Phosphorylation	LDKRNVRSPPTFISN CCCCCCCCCCCCHHH	30.83	22817900
167	Phosphorylation	RNVRSPPTFISNRLR CCCCCCCCCHHHCCC	36.66	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PLU_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLU_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLU_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCD_DROME	bcd	physical	15575970
VTU2_DROME	Vm26Ab	physical	15575970
DLL_DROME	Dll	physical	15575970
RAD51_DROME	spn-A	physical	15575970
CEG1A_DROME	CenG1A	physical	15575970
DIMM_DROME	dimm	physical	15575970
CCNC_DROME	CycC	physical	15575970
CCNE_DROME	CycE	physical	15575970
ACOX1_DROME	CG5009	physical	15575970
PAN3_DROME	CG11486	physical	15575970
PANG1_DROME	pan	physical	15575970
PANG2_DROME	pan	physical	15575970
MSIR6_DROME	Rbp6	physical	15575970
ECR_DROME	EcR	physical	15575970
CCNB_DROME	CycB	genetic	11514446

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLU_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167, AND MASSSPECTROMETRY.	18327897 [Abstract]