NOC2L_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOC2L_DROME
• UniProt AC: Q9VIF0
• Protein Name: Nucleolar complex protein 2 homolog
• Gene Name: CG9246
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 766
• Subcellular Localization: Nucleus.
• Protein Sequence: MKLATKKIKTLGKSKPDLSKKKPAKDAIRKTKPQTTSETKVTPRNPKQKVAEPVKNGKTTKKGFKKSHKEELEGLKDIDPEFYDFLKNNDKKLLDFNLLDTDDDDDEEGDEEDKEDTVTKESKDDEDDEEKYHKPSKDLEVASDESDFEVDEEDDAAAGGIQKITLNLLHQWEQQLGQANISIDIVRKVIQAFNSALASISADGADGGENKHNAAAFKVVGAAAFNGVIQLCVIHLQPAIIRLLGVRPNSSLPLHKHKKWVKVRGCLRYYLTDLIRLVEQVSSPNILGVLLKHLHQMAGMVVPFSALGKTILKRLVVLWSTGDETVRVLAFLCILKITRKQQATMLNHVLKAMYLAYVRNSKFVSPNTLPGINFMRRSLVEMFALDLNVSYQHVFLYIRQLAIHLRNAVILKKKDSFQAVYNWQFINSLRLWADLLGASANKPQLQPLIYPLVTIATGVIRLIPTAQYFPLRFHCLQTLISLAKETNTYVPVLPLIVEVLKSNTFNRKHSAVSMKPVQFTCVLRLNKGQLAENGFRDEVIEQVCGLLLEYLAHESTSLAFSDLVVPTVMAIKTYLKECRNANYARKLKQLLEKIQESARFIEQQRGKSSVTFDIKDAQAVAAWEQQLRLKRTPLDVYYASWLKTHETKKRRQAAHTDEINADYDVPKLKKLPVKTGVPVRNENGEVELFPSDSEDEGDDGLHLGSDDDDDEDVQEEEEVEVEHPKAKKAKKEKPEKQKPRPATVEDDYDEAGGAVDIVKDLDLNEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	KKIKTLGKSKPDLSK HHHHHCCCCCCCHHH	59.42	21791702
101	Phosphorylation	LDFNLLDTDDDDDEE EEEECCCCCCCCCCC	41.10	19429919
117	Phosphorylation	DEEDKEDTVTKESKD CCCCHHHCCCCCCCC	31.03	22817900
143	Phosphorylation	SKDLEVASDESDFEV CHHCEECCCCCCCCC	47.27	19429919
146	Phosphorylation	LEVASDESDFEVDEE CEECCCCCCCCCCHH	53.22	19429919
608	Phosphorylation	IEQQRGKSSVTFDIK HHHHCCCCEEEEEHH	32.63	19429919
609	Phosphorylation	EQQRGKSSVTFDIKD HHHCCCCEEEEEHHH	28.76	19429919
611	Phosphorylation	QRGKSSVTFDIKDAQ HCCCCEEEEEHHHHH	19.96	19429919
691	Phosphorylation	GEVELFPSDSEDEGD CCEEECCCCCCCCCC	46.57	22817900
693	Phosphorylation	VELFPSDSEDEGDDG EEECCCCCCCCCCCC	51.81	22817900
705	Phosphorylation	DDGLHLGSDDDDDED CCCCCCCCCCCCCCC	44.20	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOC2L_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOC2L_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOC2L_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of NOC2L_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-101; SER-143; SER-146;SER-691; SER-693 AND SER-705, AND MASS SPECTROMETRY.
PubMed: 18327897