SESN_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SESN_DROME
• UniProt AC: Q9W1K5
• Protein Name: Sestrin homolog {ECO:0000305}
• Gene Name: Sesn {ECO:0000312|FlyBase:FBgn0034897}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 497
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Functions as a negative feedback regulator of TOR function..
• Protein Sequence: MYYAVDYYADMGQISQDCFAATQTGASDFDMDELDDLDQVTQVIGYHPQFHDHFLATQNFIMKGDGPLPNDYRYYLAIIAAARHQCPYLVKRYEKEFINQGGDSAWLGGLDFIPAKLRAIYDINKILAHRPWLLRKEHIERLTKGKNSWSLSEVVHAMVLLSHFHSLSSFVFSCGLTQKLDGLSSPKLKSPPAAVAALAPTILITPTSPTEPQKGKPVLAEISLNNANPDYDSQTAASSNGGAPPDSANAVADGPDATTLNGYLATAQQLPQQHGISVETLMERMKVLSQKQDECSEAELSSRFQKVEQQTAELAAVTPEAAVGVPTNLSHYVDDANFIYQDFARRGTESINTFRIQDYSWEDHGYSLVDGLYNDVGIFLDAKFRAAYNLTYCTMGGIKNVDTSKFRRAIWNYIQCIYGIRHDDYDYGEVNQLLVRPLKMFIKTACCFPERITTKDYDSVLVELQDSEKVHVNLMIMEARNQAELLYALREIMRYMT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
184	Phosphorylation	TQKLDGLSSPKLKSP CHHCCCCCCCCCCCC	50.56	27794539
185	Phosphorylation	QKLDGLSSPKLKSPP HHCCCCCCCCCCCCH	30.97	22817900
190	Phosphorylation	LSSPKLKSPPAAVAA CCCCCCCCCHHHHHH	46.69	20203043
207	Phosphorylation	PTILITPTSPTEPQK CEEEECCCCCCCCCC	38.39	21082442
208	Phosphorylation	TILITPTSPTEPQKG EEEECCCCCCCCCCC	30.91	21082442
210	Phosphorylation	LITPTSPTEPQKGKP EECCCCCCCCCCCCC	61.13	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SESN_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SESN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SESN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
L2K1_DROME	l(2)k10201	physical	14605208
FLOT1_DROME	Flo1	physical	14605208
CP4S3_DROME	Cyp4s3	physical	14605208
PP2B2_DROME	Pp2B-14D	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185 AND SER-190, ANDMASS SPECTROMETRY.
PubMed: 18327897