RLA0_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RLA0_DROME
• UniProt AC: P19889
• Protein Name: 60S acidic ribosomal protein P0
• Gene Name: RpLP0
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 317
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Ribosomal protein P0 is the functional equivalent of E.coli protein L10..
• Protein Sequence: MVRENKAAWKAQYFIKVVELFDEFPKCFIVGADNVGSKQMQNIRTSLRGLAVVLMGKNTMMRKAIRGHLENNPQLEKLLPHIKGNVGFVFTKGDLAEVRDKLLESKVRAPARPGAIAPLHVIIPAQNTGLGPEKTSFFQALSIPTKISKGTIEIINDVPILKPGDKVGASEATLLNMLNISPFSYGLIVNQVYDSGSIFSPEILDIKPEDLRAKFQQGVANLAAVCLSVGYPTIASAPHSIANGFKNLLAIAATTEVEFKEATTIKEYIKDPSKFAAAASASAAPAAGGATEKKEEAKKPESESEEEDDDMGFGLFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
270	Acetylation	TTIKEYIKDPSKFAA CCHHHHCCCHHHHHH	63.79	21791702
280	Phosphorylation	SKFAAAASASAAPAA HHHHHHHHHHHCCCC	20.31	27794539
302	Phosphorylation	EEAKKPESESEEEDD HHHCCCCCCCCCCCC	55.75	21082442
304	Phosphorylation	AKKPESESEEEDDDM HCCCCCCCCCCCCCC	60.63	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
304	S	Phosphorylation	Kinase	CK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RLA0_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RLA0_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCAH_DROME	Nca	physical	14605208
MESD_DROME	boca	physical	22036573
GLT_DROME	Glt	physical	22036573
CLH_DROME	Chc	physical	22036573
YC17_DROME	CG16817	physical	22036573
TERA_DROME	TER94	physical	22036573
NACA_DROME	Nacalpha	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573
TCPG_DROME	Cctgamma	physical	22036573
RS10B_DROME	RpS10b	physical	22036573
PCID2_DROME	PCID2	physical	18086857

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302 AND SER-304, ANDMASS SPECTROMETRY.
PubMed: 18327897