ATPB1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPB1_DROME
• UniProt AC: Q24046
• Protein Name: Sodium/potassium-transporting ATPase subunit beta-1
• Gene Name: nrv1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 309
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein .
• Protein Description: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane..
• Protein Sequence: MSKNNGKGAKGEFEFPQPAKKQTFSEMIYNPQEGTFFGRTGKSWSQLLLFYTIFYIVLAALFTICMQGLLSTISDTEPKWKLQDSLIGTNPGLGFRPLSEQTERGSVIAFDGKKPAESDYWIELIDDFLRDYNHTEGRDMKHCGFGQVLEPTDVCVVNTDLFGGCSKANNYGYKTNQPCIFLKLNKIFGWIPEVYDKEEKDMPDDLKKVINETKTEERQQVWVSCNGHLGKDKENFQNIRYFPSQGFPSYYYPFLNQPGYLSPLVAVQFNSPPKGQMLDVECRAWAKNIQYSGSVRDRKGSVTFQILLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
133	N-linked_Glycosylation	DDFLRDYNHTEGRDM HHHHHCCCCCCCCCC	39.63	17893096
211	N-linked_Glycosylation	DDLKKVINETKTEER HHHHHHHHHCCCHHH	54.60	17893096
294	Phosphorylation	KNIQYSGSVRDRKGS HCCEEECCCCCCCCC	14.19	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPB1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPB1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPB1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
41_DROME	cora	physical	12782686
NRX4_DROME	Nrx-IV	physical	12782686

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-133 AND ASN-211, AND MASSSPECTROMETRY.
PubMed: 17893096