dbPTM

ARA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARA_DROME
UniProt AC	Q24248
Protein Name	Homeobox protein araucan
Gene Name	ara
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	717
Subcellular Localization	Nucleus .
Protein Description	Controls proneural and vein forming genes. Positive transcriptional controler of AC-SC (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the AC and SC promoters and participates in transcription initiation..
Protein Sequence	MAAYTQFGYGGFPSASQLLPPSVQTTEDASANVNVNVNEALVMTNAPAMSPTGGQDCQGSQPSGGAGGDASSGALSPNALSQNSNAATVVGAGGGSSAGGGGPADLATGGSLDGNGVGTTPTAGGAGGGGSCCENGRPIMTDPVSGQTVCSCQYDSARLALSSYSRLPAASVGVYGTPYPSTDQNPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGGLLVSNSSYGASYDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKDETKEEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLADTVGCKTPPPAYMGHQSMPLQQQQQQQQQQQQAQHQYPPSEAGRDQQLFNGAAAPYLRPHTTAYGGFLGATTQQLHTTNNSIPYSNMPPQQQQPQQQQQQLQQGGTIHTTGSSSGPIIPLQFHNRHPQQQQQLQQQSQSTASQRAMGFLEAQPDTPPQTPPNMKVLSGALSLLPTATQVPMTATCRSSNAFGFPASGYPMNFSARLGEYSPRDDYSSGNSSSSSSSSPQLQRNEAMFKPLFKKFTN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
336	Phosphorylation	DDDDALVSDDEKDKE CCCCCCCCCCCCCHH	39.95	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CCNE_DROME	CycE	genetic	26305360

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARA_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336, AND MASSSPECTROMETRY.	18327897 [Abstract]