HMDH_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HMDH_DROME
• UniProt AC: P14773
• Protein Name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
• Gene Name: Hmgcr
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 920
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm..
• Protein Sequence: MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDKNNTLDASSGLGTATASAAAAGGSGSGAGSGASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQAEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFYPACLSLIFDLSRSGVDMSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVHIYSRVAFSGSDYDAVDKTLTPTLSLNVSNNRTESGEIADIIIKWLTMSADHIVISIVLIALVVKFICFDNRDPLPDQLRQSGPVAIAAKASQTTPIDEEHVEQEKDTENSAAVRTLLFTIEDQSSANASTQTDLLPLRHRLVGPIKPPRPVQECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSANNPLNVTVSSCSTIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	N-linked_Glycosylation	CMLTVDKNNTLDASS HHHHCCCCCCCCCCC	42.10	-
342	N-linked_Glycosylation	LTPTLSLNVSNNRTE CCCEEEEECCCCCCC	31.62	-
346	N-linked_Glycosylation	LSLNVSNNRTESGEI EEEECCCCCCCCCHH	44.75	-
443	N-linked_Glycosylation	IEDQSSANASTQTDL ECCCCCCCCCCCCCC	36.05	-
475	N-linked_Glycosylation	QECLDILNSTEEGSG HHHHHHHHCCCCCCC	47.41	-
797	N-linked_Glycosylation	TGQDPAQNVTSSNCS CCCCHHHCCCCCCCC	40.93	-
802	N-linked_Glycosylation	AQNVTSSNCSTAMEC HHCCCCCCCCHHHHH	24.43	-
896	N-linked_Glycosylation	VKSHMRHNRSSIAVN HHHHHCCCCCCEEEE	34.85	-
910	N-linked_Glycosylation	NSANNPLNVTVSSCS ECCCCCCEEEEEECC	28.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HMDH_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HMDH_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HMDH_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDR49_DROME	Mdr49	genetic	19213920
HH_DROME	hh	genetic	16256738
DISP_DROME	disp	genetic	16256738

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.