PIPA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIPA_DROME
• UniProt AC: P13217
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase {ECO:0000305}
• Gene Name: norpA {ECO:0000312|FlyBase:FBgn0262738}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1095
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. [PubMed: 2457447 Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection]
• Protein Sequence: MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAAAPAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDPFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAAIDKLIKGKSKDDIRNDANIKNSINDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKALMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKLMDMYKIEEEAYKTQGKTEFYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
204	Phosphorylation	LPDDKNATMTKEQFT CCCCCCCCCCHHHHH	34.46	19429919
206	Phosphorylation	DDKNATMTKEQFTFD CCCCCCCCHHHHHHH	27.37	19429919
846	Phosphorylation	ALGIEEQSGGAARDA HCCCCHHCCCCCCHH	42.34	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIPA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIPA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIPA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHK1_DROME	ball	physical	14605208
INAD_DROME	inaD	physical	9796815
DGK2_DROME	rdgA	genetic	12441057
AP2A_DROME	AP-2alpha	genetic	16835270
CATL_DROME	Cp1	genetic	22426392
TULP_DROME	ktub	genetic	23228091
ARRB_DROME	Arr2	genetic	11086989
ARRB_DROME	Arr2	genetic	12848937
ARRB_DROME	Arr2	genetic	16835270
TRPA1_DROME	TrpA1	genetic	18660806
DRONC_DROME	Nc	genetic	14724249
RDGC_DROME	rdgC	genetic	18660806
CYTL_DROME	Cys	genetic	22426392
CRY1_DROME	cry	genetic	10839367
OPS1_DROME	ninaE	genetic	7695903
OPS1_DROME	ninaE	genetic	22855823
NCASE_DROME	CDase	genetic	12637747
INAD_DROME	inaD	physical	9356510
INAD_DROME	inaD	physical	9545241
INAD_DROME	inaD	physical	9679151
INAD_DROME	inaD	physical	9010208
TRP_DROME	trp	physical	9010208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.