KPC2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPC2_DROME
• UniProt AC: P13677
• Protein Name: Protein kinase C, eye isozyme
• Gene Name: inaC
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 700
• Protein Description: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection. [PubMed: 25639794]
• Protein Sequence: MAAAAVATPGATVLPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFITII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAAAVATPGATVLP CCCCCCCCCCCEECC	18.69	27794539
665	Ubiquitination	NFDDAFTKEKTDLTP CCCHHHHCCCCCCCC	51.24	31113955
668	Phosphorylation	DAFTKEKTDLTPTDK HHHHCCCCCCCCCCE	37.01	27794539
671	Phosphorylation	TKEKTDLTPTDKLFM HCCCCCCCCCCEEEE	27.27	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPC2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPC2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPC2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2A_DROME	mts	genetic	18256265
INAD_DROME	inaD	physical	11342563
INAD_DROME	inaD	physical	10766855
INAD_DROME	inaD	physical	16914683
INAD_DROME	inaD	physical	9651370
TRP_DROME	trp	physical	10766855
TRP_DROME	trp	physical	16914683

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.