dbPTM

ITPA_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ITPA_DROME
UniProt AC	Q9VMW7
Protein Name	Inosine triphosphate pyrophosphatase {ECO:0000255\|HAMAP-Rule:MF_03148}
Gene Name	CG8891
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	191
Subcellular Localization	Cytoplasm .
Protein Description	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions..
Protein Sequence	MSKPITFVTGNAKKLEELVAILGPSFPRTIVSKKIDLPELQGDIDEIAIKKCKEAARQVNGPVLVEDTSLCFNALEGLPGPYIKWFLEKLQPEGLHRLLHGWENKSAQAICTFGYCDGVDAEPLIFKGITEGVIVEPRGPRDFGWDPVFQPSGYDKTYAELPKSEKNTISHRYRALALLRQHFEKQDKLIN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
3	Acetylation	-----MSKPITFVTG -----CCCCEEEECC	38.86	21791702
163	Acetylation	KTYAELPKSEKNTIS CCHHCCCHHHCCCHH	81.51	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ITPA_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ITPA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ITPA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SH3BG_DROME	Sh3beta	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ITPA_DROME

Related Literatures of Post-Translational Modification