dbPTM

UCHL_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UCHL_DROME
UniProt AC	P35122
Protein Name	Ubiquitin carboxyl-terminal hydrolase
Gene Name	Uch
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	227
Subcellular Localization
Protein Description	Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin..
Protein Sequence	MLTWTPLESNPEVLTKYIHKLGVSPAWSVTDVIGLEDDTLEWIPRPVKAFILLFPCSETYEKHRAEEHDRIKEVEEQHPEDLFYMRQFTHNACGTVALIHSVANNKEVDIDRGVLKDFLEKTASLSPEERGRALEKDEKFTADHEALAQEGQTNAANHEKVIHHFIALVNKEGTLYELDGRKSFPIKHGPTSEETFVKDAAKVCKEFMARDPNEVRFTVLALTAAQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
89	Phosphorylation	LFYMRQFTHNACGTV HHHHHHHCCCCHHHH	13.09	21082442
126	Phosphorylation	LEKTASLSPEERGRA HHHHHCCCHHHHHHH	27.98	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UCHL_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UCHL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UCHL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH3BG_DROME	Sh3beta	physical	22036573
NACA_DROME	Nacalpha	physical	22036573
MOEH_DROME	Moe	physical	22036573
PDI_DROME	Pdi	physical	22036573
NLP_DROME	Nlp	physical	22036573
HCD2_DROME	scu	physical	22036573
EF1D_DROME	eEF1delta	physical	22036573
PSA6_DROME	Prosalpha1	physical	22036573
INO1_DROME	Inos	physical	22036573
FAXC_DROME	fax	physical	22036573
THIO2_DROME	Trx-2	physical	22036573
PGK_DROME	Pgk	physical	22036573
TERA_DROME	TER94	physical	22036573
FKB12_DROME	FK506-bp2	physical	22036573
RL40_HUMAN	UBA52	physical	10527495

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UCHL_DROME

Related Literatures of Post-Translational Modification