EOGT_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EOGT_DROME
• UniProt AC: Q9VQB7
• Protein Name: EGF domain-specific O-linked N-acetylglucosamine transferase
• Gene Name: Eogt
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 520
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp)..
• Protein Sequence: MPILPILIGILHLSLAEDAKHLDGFSLPSLPSEHLIRYLNTFPKLKQQLPTNLTGKGTISSACWGHERDCTPAGRFQTPQCPGEHTGWARSKEAQVRTFYNQADFGYIQEQLSQLTPQCVPTYLGDSSLECTHYLRFCRGRNLLFDFRGLEQREERIRYHMDVLGPGQLLGHCKLNRTRLSGEMEHIGSALQSWGPELRNFDVLPHPVLESGLCDVVVNTPTFIMKIDATYNMYHHFCDFFNLYASLFVNQSHPAAFNTDVQILIWETYPYDSPFRDTFKAFSQRPVWTLSDVEGKRVCFKNVVLPLLPRMIFGLFYNTPIIQGCSNSGLFRAFSEFILHRLQIPYKPPQQKIRITYLSRRTKYRQVLNEDELLAPLEANDKYDVQRVSYERLPFTNQLAITRNTDILIGMHGAGLTHLLFLPNWACIFELYNCEDPNCYKDLARLRGVRYRTWEQRDLVYPQDEGHHPEGGAHAKFTNYSFDVKEFVHLVDGAAEEILSHKEFPRRASENPSKTQRNEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	KLKQQLPTNLTGKGT HHHHHCCCCCCCCCC	51.99	22817900
52	N-linked_Glycosylation	LKQQLPTNLTGKGTI HHHHCCCCCCCCCCC	33.40	-
176	N-linked_Glycosylation	LLGHCKLNRTRLSGE EECEEECCCCCCCCC	28.86	-
250	N-linked_Glycosylation	LYASLFVNQSHPAAF HHHHHHCCCCCCCCC	30.24	-
479	N-linked_Glycosylation	GAHAKFTNYSFDVKE CCCCEEECEEEEHHH	33.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EOGT_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EOGT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EOGT_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	physical	22158438

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.