dbPTM

UMPS_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UMPS_DROME
UniProt AC	Q01637
Protein Name	Uridine 5'-monophosphate synthase
Gene Name	r-l
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	493
Subcellular Localization
Protein Description
Protein Sequence	MVAQNSDKMRALALKLFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGVPYTALPLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILDTVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEKSTVEAVAKYIAAVQINSDGTFVGGDKGDVVRANDLQRTKLTYENRANLAKSAVAKRLFNLIASKQTNLCLAADLTHADEILDVADKCGPYICLLKTHVDIVEDFSDKFIADLQALAQRHNFLLMEDRKFADIGNTVSLQYGKGIYKISSWADLVTAHTLPGRSILQGLKAGLGEGGAGKERGVFLLAEMSASGNLIDAKYKENSNKIATEGADVDFVAGVVCQSSDAFAFPGLLQLTPGVKIDEGVDQLGQQYQSPEHVVKERGADIGVVGRGILKASSPKQAAQTYRDRLWAAYQDRVAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Acetylation	LFEINAFKFGDFKMK HHHCCCEECCCEEEE	46.13	21791702
166	Acetylation	GGVANIAKHGVRMHS CCCHHHHHHCCCHHH	36.77	21791702
209	Phosphorylation	IAAVQINSDGTFVGG HEEEEECCCCCEECC	38.76	22817900
212	Phosphorylation	VQINSDGTFVGGDKG EEECCCCCEECCCCC	21.82	22817900
340	Phosphorylation	GKGIYKISSWADLVT CCCEEEECCHHHHHH	18.71	19429919
341	Phosphorylation	KGIYKISSWADLVTA CCEEEECCHHHHHHH	29.74	19429919
447	Phosphorylation	QLGQQYQSPEHVVKE HHHHHCCCHHHHHHH	27.59	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UMPS_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UMPS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UMPS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPS1_DROME	SelD	physical	22036573
SGG_DROME	sgg	physical	22036573
CARME_DROME	CG11596	physical	22036573
RIR2_DROME	RnrS	physical	22036573

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UMPS_DROME

Related Literatures of Post-Translational Modification