CARME_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARME_DROME
• UniProt AC: Q9I7X6
• Protein Name: Carnosine N-methyltransferase {ECO:0000250|UniProtKB:Q5BJZ6}
• Gene Name: CG11596
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 439
• Protein Description: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine..
• Protein Sequence: MSSMDCATFPMHPKMDEQLARTFVINEEEEEKHIQKVQNAFLYYGPYACQRLKRSMDYLNSLSGEDQIMLAKYRGHLECVRTCIDRNQAVIREILRGRVLYPTDEATGDPSEFDEPPPNVRHGDMDQAQSTLKLIARDWSTEGALEREQSYKPIIDSIVAYFKHSDFELKDIKILVPGAGLGRLTYELACLGYSCEGNEFSYFMLIASNFVLNLCDNENKYVLYPWVHQYVNNLRREDQVAPVRFPDVCPLKNPPKGHFEIAAGDFLEVYKTPNAYNCVATCFFIDCANNVIDFIRTIYKILVPGGIWVNLGPLLYHFSDVSGQNSIEPAFEDLCIIMESVGFVIEKSRTGIRTKYAQNPSSMKQSEYQSLFWVCRKPDLFEEQRGKRKASREPHDLIVREDSEEEGEQQPERNETEEKQQLKPLATANCETEIKEQPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
144 (in isoform 2)	Acetylation	-		-
391	Phosphorylation	QRGKRKASREPHDLI HHCCCCCCCCCCCEE		22817900
403	Phosphorylation	DLIVREDSEEEGEQQ CEEECCCCHHHCCCC		21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARME_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARME_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARME_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNAS_DROME	Sh	physical	14605208
SISA_DROME	sisA	physical	14605208
PELI_DROME	Pli	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.