ARP3_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP3_DROME
• UniProt AC: P32392
• Protein Name: Actin-related protein 3
• Gene Name: Arp3 {ECO:0000312|FlyBase:FBgn0262716}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 418
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline. [PubMed: 25739458]
• Protein Sequence: MAGRLPACVIDVGTGYSKLGFAGNKEPQFIIPSAIAIKESARVGDTNTRRITKGIEDLDFFIGDEAFDATGYSIKYPVRHGLVEDWDLMERFLEQCVFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWASRSAEERTLTGIVVDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRNITSFIQSLLREREVGIPPEQSLETAKAIKEKHCYICPDIAKEFAKYDTEPGKWIRNFSGVNTVTKAPFNVDVGYERFLGPEIFFHPEFSNPDFTIPLSEIVDNVIQNCPIDVRRPLYNNIVLSGGSTMFKDFGRRLQRDIKRSVDTRLRISENLSEGRIKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKAAYEEYGPSICRHNPVFGTMT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	ESARVGDTNTRRITK HHCCCCCCCCHHHHC	32.34	22817900
48	Phosphorylation	ARVGDTNTRRITKGI CCCCCCCCHHHHCCC	24.34	22817900
201	Phosphorylation	PIAGRNITSFIQSLL CCCCCCHHHHHHHHH	22.57	19429919
202	Phosphorylation	IAGRNITSFIQSLLR CCCCCHHHHHHHHHH	19.29	19429919
206	Phosphorylation	NITSFIQSLLREREV CHHHHHHHHHHHCCC	25.26	21082442
244	Acetylation	DIAKEFAKYDTEPGK HHHHHHHHCCCCCCC	49.32	21791702
244	Acetylation	DIAKEFAKYDTEPGK HHHHHHHHCCCCCCC	49.32	-
251	Acetylation	KYDTEPGKWIRNFSG HCCCCCCCEEECCCC	50.60	21791702
251	Acetylation	KYDTEPGKWIRNFSG HCCCCCCCEEECCCC	50.60	-
329	Ubiquitination	SGGSTMFKDFGRRLQ CCCCHHHHHHHHHHH	41.13	31113955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP3_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PROF_DROME	chic	physical	14605208
ARPC2_DROME	Arpc2	physical	22036573
EFHD2_DROME	Swip-1	physical	22036573
CAPZA_DROME	cpa	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.