ARPC2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARPC2_DROME
• UniProt AC: Q9VIM5
• Protein Name: Actin-related protein 2/3 complex subunit 2
• Gene Name: Arpc2
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 301
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity)..
• Protein Sequence: MILLEINNRIIEETLLVKYRNAQAGLKPESIDIRIADFDGVLYHISNVNGDKTKVRISISLKFYKQLQEHGADELLKREYGSLLTDTEEGYNVSVLINLEEIPEDCEQIAKRIGLLKRNCFASVFEKYFDYQEQGEEGQKRAVINYRNDETLYVEAKPDRVTVVFSTIFRDEDDVIIGKVFMQELREGRRASHTAPQVLFSHREPPLELANTDARVGDNIGYVTFVLFPRHTNKETRDNTINLIHMFRDYLHYHIKCSKAYIHSRMRAKTSDFLKVLNRARPEPKNTEKKTITGRTFKRID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Acetylation	RNAQAGLKPESIDIR HCCCCCCCCCCCCEE	45.91	21791702
275	Acetylation	AKTSDFLKVLNRARP HHHHHHHHHHHHCCC	44.67	21791702

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARPC2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARPC2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARPC2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALR_DROME	Crc	physical	14605208
CAPZA_DROME	cpa	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.