TREA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TREA_DROME
• UniProt AC: Q9W2M2
• Protein Name: Trehalase
• Gene Name: Treh
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 596
• Protein Sequence: MFKLPTISLLLVSWSCLVALSQAKTYSLPDLTTDYNNAIPVDEEEAQDPFASCKIYCEGNLLHTIQTAVPKLFADSKTFVDMKLNNSPDKTLEDFNAMMEAKNQTPSSEDLKQFVDKYFSAPGTELEKWTPTDWKENPSFLDLISDPDLKQWGVELNSIWKDLGRKMKDEVSKNPEYYSIIPVPNPVIVPGGRFIEFYYWDSYWIIRGLLYSQMFDTARGMIENFFSIVNRFGFIPNGGRVYYHGRSQPPLLTGMVKSYVDFTNDDKFAIDALDTLEHEFEFFVNNHNVTVKNHSLCVYRDSSSGPRPESYREDVETGEEFPTDEAKELHYSELKAGAESGMDFSSRWFISPTGTNDGNRSALSTTSIVPVDLNAYLYWNAKLIAEFHSKAGNTKKVTEYETKAEKLLLGIQEVLWNEEAGVWLDYDMINQKPRDYYTPTNLSPLWVKAFNISESEKISASVMAYIERNKLDSFPGGVPNTLSYTGEQWDAPNVWAPMQYILVEGLNNLNTPEAKNMSLKWATRWVKTNFAAFSKDRHMYEKYNADEFGVGGGGGEYEVQTGFGWSNGVIIEWLSKHGRDISIGSGCGCLAGEKRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	52.86	27794539
107	Phosphorylation	EAKNQTPSSEDLKQF HHHHCCCCHHHHHHH	50.15	27794539
118	Phosphorylation	LKQFVDKYFSAPGTE HHHHHHHHHCCCCCC	9.78	19429919
120	Phosphorylation	QFVDKYFSAPGTELE HHHHHHHCCCCCCCC	30.39	19429919
124	Phosphorylation	KYFSAPGTELEKWTP HHHCCCCCCCCCCCC	36.02	19429919
288	N-linked_Glycosylation	EFFVNNHNVTVKNHS EEEECCCCEEEEECE	33.02	-
293	N-linked_Glycosylation	NHNVTVKNHSLCVYR CCCEEEEECEEEEEE	26.16	-
359	N-linked_Glycosylation	PTGTNDGNRSALSTT CCCCCCCCCCCCCCC	37.28	-
451	N-linked_Glycosylation	PLWVKAFNISESEKI HHHEEECCCCHHHHC	41.56	17893096
516	N-linked_Glycosylation	LNTPEAKNMSLKWAT CCCHHHHHCCHHHHH	32.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TREA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TREA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TREA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HPF1_DROME	CG1218	physical	22036573
RS21_DROME	RpS21	physical	22036573
THIO2_DROME	Trx-2	physical	22036573
F10A1_DROME	HIP-R	physical	22036573
F10A2_DROME	HIP-R	physical	22036573
OTU1_DROME	CG4603	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-451, AND MASSSPECTROMETRY.
PubMed: 17893096