SHOX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHOX2_HUMAN
• UniProt AC: O60902
• Protein Name: Short stature homeobox protein 2
• Gene Name: SHOX2
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Subcellular Localization: Nucleus.
• Protein Description: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation..
• Protein Sequence: MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEELTAFVSKSF ---CHHHHHHHHHHH	22.71	26074081
9	Phosphorylation	EELTAFVSKSFDQKV HHHHHHHHHHHHHHH	19.01	26074081
11	Phosphorylation	LTAFVSKSFDQKVKE HHHHHHHHHHHHHHH	26.92	26074081
52	Phosphorylation	EAGRDDRSSPAVRAA CCCCCCCCCCCHHCC	47.90	22210691
53	Phosphorylation	AGRDDRSSPAVRAAG CCCCCCCCCCHHCCC	20.13	22210691
92	Phosphorylation	GGAGGGRSPVRELDM CCCCCCCCCCCCCCC	30.90	30108239
114	Phosphorylation	EPGSPRLTEVSPELK CCCCCCCCCCCHHHH	35.30	29083192
117	Phosphorylation	SPRLTEVSPELKDRK CCCCCCCCHHHHCHH	13.36	24719451
143	Phosphorylation	TKIKQRRSRTNFTLE HHHHHHHHCCCCCHH	45.72	-
148	Phosphorylation	RRSRTNFTLEQLNEL HHHCCCCCHHHHHHH	31.30	-
164	Phosphorylation	RLFDETHYPDAFMRE HHHCCCCCCCHHHHH	15.38	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHOX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHOX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHOX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI29_HUMAN	TRIM29	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.