RPRM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPRM_HUMAN
• UniProt AC: Q9NS64
• Protein Name: Protein reprimo
• Gene Name: RPRM
• Organism: Homo sapiens (Human).
• Sequence Length: 109
• Subcellular Localization: Cytoplasm. Membrane ; Single-pass membrane protein .
• Protein Description: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity)..
• Protein Sequence: MNPALGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	N-linked_Glycosylation	-MNPALGNQTDVAGL -CCCCCCCCCCHHHH	42.29	UniProtKB CARBOHYD
18	N-linked_Glycosylation	VAGLFLANSSEALER HHHHEECCCHHHHHH	48.49	UniProtKB CARBOHYD
98	Phosphorylation	LVKDRRPSKEVEAVV HHCCCCCCCCEEEEE	39.37	24275748
99	Ubiquitination	VKDRRPSKEVEAVVV HCCCCCCCCEEEEEE	69.34	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPRM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPRM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPRM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	17353931
FBW1B_HUMAN	FBXW11	physical	17353931
CDK4_HUMAN	CDK4	physical	17353931
TMM79_HUMAN	TMEM79	physical	25416956
FATE1_HUMAN	FATE1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.