CDN2D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDN2D_HUMAN
• UniProt AC: P55273
• Protein Name: Cyclin-dependent kinase 4 inhibitor D
• Gene Name: CDKN2D
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Interacts strongly with CDK4 and CDK6 and inhibits them..
• Protein Sequence: MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLLEEVRA -------CCCCCHHC	9.70	12665801
66	Phosphorylation	ELLKQGASPNVQDTS HHHHCCCCCCCCCCC	24.67	22817900
73	Phosphorylation	SPNVQDTSGTSPVHD CCCCCCCCCCCCHHH	48.65	30576142
75	Phosphorylation	NVQDTSGTSPVHDAA CCCCCCCCCCHHHHH	29.62	30576142
76	Phosphorylation	VQDTSGTSPVHDAAR CCCCCCCCCHHHHHH	28.57	22817900
84	Phosphorylation	PVHDAARTGFLDTLK CHHHHHHCCHHHHHH	27.79	30576142
89	Phosphorylation	ARTGFLDTLKVLVEH HHCCHHHHHHHHHHC	30.53	-
141	Phosphorylation	RRDARGLTPLELALQ HCCCCCCCHHHHHHH	28.75	22558186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
76	S	Phosphorylation	Kinase	CDK1	P06493	PSP
76	S	Phosphorylation	Kinase	CDK2	P24941	PSP
141	T	Phosphorylation	Kinase	PRKACA	P00517	GPS
141	T	Phosphorylation	Kinase	PKACA	P17612	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDN2D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDN2D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBC17_HUMAN	TBC1D17	physical	16189514
BRCA1_HUMAN	BRCA1	physical	17334399
A4_HUMAN	APP	physical	21832049
CDK4_HUMAN	CDK4	physical	23718855
NR4A1_HUMAN	NR4A1	physical	25416956
NR4A2_HUMAN	NR4A2	physical	25416956
IKZF3_HUMAN	IKZF3	physical	25416956
DHB14_HUMAN	HSD17B14	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
IKZF3_HUMAN	IKZF3	physical	21516116
CA094_HUMAN	C1orf94	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides.";
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.;
Nat. Biotechnol. 21:566-569(2003).
Cited for: PROTEIN SEQUENCE OF 1-7, AND ACETYLATION AT MET-1.
PubMed: 12665801