CACB3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACB3_RAT
• UniProt AC: P54287
• Protein Name: Voltage-dependent L-type calcium channel subunit beta-3
• Gene Name: Cacnb3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 484
• Protein Description: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting..
• Protein Sequence: MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLDDACEHLAEYLEVYWRATHHPAPGPGMLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHDHNDRNWQRNRPWPKDSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	Phosphorylation	QEQKARRSGNPSSLS HHHHHHHCCCCCHHH	37.05	28432305
142	Phosphorylation	ARRSGNPSSLSDIGN HHHCCCCCHHHHCCC	48.16	28432305
143	Phosphorylation	RRSGNPSSLSDIGNR HHCCCCCHHHHCCCC	32.90	28432305
145	Phosphorylation	SGNPSSLSDIGNRRS CCCCCHHHHCCCCCC	29.18	28432305
152	Phosphorylation	SDIGNRRSPPPSLAK HHCCCCCCCCHHHHH	38.22	27097102
156	Phosphorylation	NRRSPPPSLAKQKQK CCCCCCHHHHHHHHH	46.89	26437020
205	Acetylation	KALFDFLKHRFDGRI HHHHHHHHHHCCCCC	32.50	-
245	Phosphorylation	IERSSARSSIAEVQS EECHHCCHHHHHHHH	26.30	25403869
246	Phosphorylation	ERSSARSSIAEVQSE ECHHCCHHHHHHHHH	21.92	25403869
393	Phosphorylation	GERGEEHSPLERDSL CCCCCCCCCCCHHCC	34.16	25403869
403	Phosphorylation	ERDSLMPSDEASESS CHHCCCCCCHHCHHH	33.83	22673903
407	Phosphorylation	LMPSDEASESSRQAW CCCCCHHCHHHHHHH	35.64	22673903
409	Phosphorylation	PSDEASESSRQAWTG CCCHHCHHHHHHHHC	28.46	22673903
410	Phosphorylation	SDEASESSRQAWTGS CCHHCHHHHHHHHCC	25.10	22673903
429	Phosphorylation	SRHLEEDYADAYQDL HHHHCHHHHHHHHHH	15.06	-
464	Phosphorylation	DRLLAQDSEHDHNDR HCHHHCCCCCCCCCC	25.42	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACB3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACB3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACB3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX6_HUMAN	PAX6	physical	19917615

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.