RIPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIPR1_HUMAN
• UniProt AC: Q6ZS17
• Protein Name: Rho family-interacting cell polarization regulator 1
• Gene Name: RIPOR1
• Organism: Homo sapiens (Human).
• Sequence Length: 1223
• Subcellular Localization: Cytoplasm . Golgi apparatus . Localizes to the podocyte major processes and cell body (By similarity). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26
• Protein Description: Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. [PubMed: 27807006 Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation]
• Protein Sequence: MMSLSVRPQRRLLSARVNRSQSFAGVLGSHERGPSLSFRSFPVFSPPGPPRKPPALSRVSRMFSVAHPAAKVPQPERLDLVYTALKRGLTAYLEVHQQEQEKLQGQIRESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYTTGSPGSREARDSLAEATRGHREYTESMCLLESELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIEGSGKQVWDSEETIFLPLLTEFLSIKVTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVTWSPFDKDDQPSAASSVNKASTVTKRFSTYSQSPPDTPSLREQAFYNMLRRQEELENGTAWSLSSESSDDSSSPQLSGTARHSPAPRPLVQQPEPLPIQVAFRRPETPSSGPLDEEGAVAPVLANGHAPYSRTLSHISEASVDAALAEASVEAVGPESLAWGPSPPTHPAPTHGEHPSPVPPALDPGHSATSSTLGTTGSVPTSTDPAPSAHLDSVHKSTDSGPSELPGPTHTTTGSTYSAITTTHSAPSPLTHTTTGSTHKPIISTLTTTGPTLNIIGPVQTTTSPTHTMPSPTHTTASPTHTSTSPTHTPTSPTHKTSMSPPTTTSPTPSGMGLVQTATSPTHPTTSPTHPTTSPILINVSPSTSLELATLSSPSKHSDPTLPGTDSLPCSPPVSNSYTQADPMAPRTPHPSPAHSSRKPLTSPAPDPSESTVQSLSPTPSPPTPAPQHSDLCLAMAVQTPVPTAAGGSGDRSLEEALGALMAALDDYRGQFPELQGLEQEVTRLESLLMQRQGLTRSRASSLSITVEHALESFSFLNEDEDEDNDVPGDRPPSSPEAGAEDSIDSPSARPLSTGCPALDAALVRHLYHCSRLLLKLGTFGPLRCQEAWALERLLREARVLEAVCEFSRRWEIPASSAQEVVQFSASRPGFLTFWDQCTERLSCFLCPVERVLLTFCNQYGARLSLRQPGLAEAVCVKFLEDALGQKLPRRPQPGPGEQLTVFQFWSFVETLDSPTMEAYVTETAEEVLLVRNLNSDDQAVVLKALRLAPEGRLRRDGLRALSSLLVHGNNKVMAAVSTQLRSLSLGPTFRERALLCFLDQLEDEDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHRRLEESLDALPRIFGPGSMASTAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 4)	Phosphorylation	-		29083192
5	Phosphorylation	---MMSLSVRPQRRL ---CCCCCCCHHHHH		24719451
12 (in isoform 3)	Phosphorylation	-		29523821
14	Phosphorylation	RPQRRLLSARVNRSQ CHHHHHHHHHHCCCC		24719451
14 (in isoform 3)	Phosphorylation	-		29523821
17 (in isoform 3)	Phosphorylation	-		27251275
19 (in isoform 3)	Phosphorylation	-		27251275
20	Phosphorylation	LSARVNRSQSFAGVL HHHHHCCCCCHHHCC		30266825
20 (in isoform 2)	Phosphorylation	-		21949786
22	Phosphorylation	ARVNRSQSFAGVLGS HHHCCCCCHHHCCCC		23401153
22 (in isoform 2)	Phosphorylation	-		28355574
23 (in isoform 4)	Phosphorylation	-		27251275
25 (in isoform 4)	Phosphorylation	-		27251275
29	Phosphorylation	SFAGVLGSHERGPSL CHHHCCCCCCCCCCC		23403867
34 (in isoform 3)	Phosphorylation	-		21949786
36	Phosphorylation	SHERGPSLSFRSFPV CCCCCCCCCCCCCCC		32645325
36 (in isoform 3)	Phosphorylation	-		28355574
37	Phosphorylation	HERGPSLSFRSFPVF CCCCCCCCCCCCCCC		24719451
40 (in isoform 4)	Phosphorylation	-		21949786
41 (in isoform 2)	Phosphorylation	-		30153514
42	Phosphorylation	SLSFRSFPVFSPPGP CCCCCCCCCCCCCCC		32645325
45	Phosphorylation	FRSFPVFSPPGPPRK CCCCCCCCCCCCCCC		23403867
55 (in isoform 3)	Phosphorylation	-		30153514
61 (in isoform 4)	Phosphorylation	-		30153514
64	Phosphorylation	SRVSRMFSVAHPAAK HHHHHHHHCCCCCCC		28857561
110	Phosphorylation	LQGQIRESKRNSRLG HHHHHHHHHHHCCHH		24670416
114	Phosphorylation	IRESKRNSRLGFLYD HHHHHHHCCHHHHHH		23403867
120	Phosphorylation	NSRLGFLYDLDKQVK HCCHHHHHHHHHHHH		23403867
128	Phosphorylation	DLDKQVKSIERFLRR HHHHHHHHHHHHHHH		24825855
167	Phosphorylation	AYNMVRAYTTGSPGS CCCCHHHHCCCCCCC		27251275
168	Phosphorylation	YNMVRAYTTGSPGSR CCCHHHHCCCCCCCH		29396449
169	Phosphorylation	NMVRAYTTGSPGSRE CCHHHHCCCCCCCHH		22199227
171	Phosphorylation	VRAYTTGSPGSREAR HHHHCCCCCCCHHHH		26055452
174	Phosphorylation	YTTGSPGSREARDSL HCCCCCCCHHHHHHH		22199227
248	Phosphorylation	LRGRIEGSGKQVWDS EECEEECCCCCCCCC		23403867
315	Phosphorylation	DLGTIKLSLEVTWSP HCCCEEEEEEEEECC		30576142
330	Phosphorylation	FDKDDQPSAASSVNK CCCCCCCCHHHHCCH		29743597
333	Phosphorylation	DDQPSAASSVNKAST CCCCCHHHHCCHHHH		28450419
333	Ubiquitination	DDQPSAASSVNKAST CCCCCHHHHCCHHHH		29967540
334	Phosphorylation	DQPSAASSVNKASTV CCCCHHHHCCHHHHC		21815630
337	Ubiquitination	SAASSVNKASTVTKR CHHHHCCHHHHCHHH		29967540
340	Phosphorylation	SSVNKASTVTKRFST HHCCHHHHCHHHHCC		30576142
342	Phosphorylation	VNKASTVTKRFSTYS CCHHHHCHHHHCCCC		30576142
346	Phosphorylation	STVTKRFSTYSQSPP HHCHHHHCCCCCCCC		23927012
347	Phosphorylation	TVTKRFSTYSQSPPD HCHHHHCCCCCCCCC		29255136
347	Ubiquitination	TVTKRFSTYSQSPPD HCHHHHCCCCCCCCC		29967540
348	Phosphorylation	VTKRFSTYSQSPPDT CHHHHCCCCCCCCCC		22167270
349	Phosphorylation	TKRFSTYSQSPPDTP HHHHCCCCCCCCCCH		22167270
351	Phosphorylation	RFSTYSQSPPDTPSL HHCCCCCCCCCCHHH		29255136
353	Ubiquitination	STYSQSPPDTPSLRE CCCCCCCCCCHHHHH		29967540
355	Phosphorylation	YSQSPPDTPSLREQA CCCCCCCCHHHHHHH		29255136
357	Phosphorylation	QSPPDTPSLREQAFY CCCCCCHHHHHHHHH		29255136
361	Phosphorylation	DTPSLREQAFYNMLR CCHHHHHHHHHHHHH		32142685
364	Phosphorylation	SLREQAFYNMLRRQE HHHHHHHHHHHHHHH		28796482
367	Phosphorylation	EQAFYNMLRRQEELE HHHHHHHHHHHHHHH		32142685
377	Phosphorylation	QEELENGTAWSLSSE HHHHHCCCCCCCCCC		30624053
380	Phosphorylation	LENGTAWSLSSESSD HHCCCCCCCCCCCCC		30624053
382	Phosphorylation	NGTAWSLSSESSDDS CCCCCCCCCCCCCCC		30624053
383	Phosphorylation	GTAWSLSSESSDDSS CCCCCCCCCCCCCCC		30624053
385	Phosphorylation	AWSLSSESSDDSSSP CCCCCCCCCCCCCCC		30624053
386	Phosphorylation	WSLSSESSDDSSSPQ CCCCCCCCCCCCCCC		30624053
389	Phosphorylation	SSESSDDSSSPQLSG CCCCCCCCCCCCCCC		30624053
390	Phosphorylation	SESSDDSSSPQLSGT CCCCCCCCCCCCCCC		30624053
391	Phosphorylation	ESSDDSSSPQLSGTA CCCCCCCCCCCCCCC		30624053
397	Phosphorylation	SSPQLSGTARHSPAP CCCCCCCCCCCCCCC		24532841
401	Phosphorylation	LSGTARHSPAPRPLV CCCCCCCCCCCCCCC		29255136
425	Phosphorylation	VAFRRPETPSSGPLD EEEECCCCCCCCCCC		21945579
427	Phosphorylation	FRRPETPSSGPLDEE EECCCCCCCCCCCCC		21945579
428	Phosphorylation	RRPETPSSGPLDEEG ECCCCCCCCCCCCCC		21945579
448	Phosphorylation	LANGHAPYSRTLSHI HCCCCCCCCCCHHHH		21945579
449	Phosphorylation	ANGHAPYSRTLSHIS CCCCCCCCCCHHHHC		21945579
451	Phosphorylation	GHAPYSRTLSHISEA CCCCCCCCHHHHCHH		22468782
453	Phosphorylation	APYSRTLSHISEASV CCCCCCHHHHCHHHH		17001009
456	Phosphorylation	SRTLSHISEASVDAA CCCHHHHCHHHHHHH		22468782
459	Phosphorylation	LSHISEASVDAALAE HHHHCHHHHHHHHHH		22468782
565	Phosphorylation	SAITTTHSAPSPLTH EEEEECCCCCCCCCC		25627689
568	Phosphorylation	TTTHSAPSPLTHTTT EECCCCCCCCCCCCC		25627689
589	Phosphorylation	IISTLTTTGPTLNII EEEEEECCCCCEEEE		30576142
615	Phosphorylation	TMPSPTHTTASPTHT CCCCCCCCCCCCCCC		30576142
698	Phosphorylation	LSSPSKHSDPTLPGT CCCCCCCCCCCCCCC		23663014
701	Phosphorylation	PSKHSDPTLPGTDSL CCCCCCCCCCCCCCC		23663014
705	Phosphorylation	SDPTLPGTDSLPCSP CCCCCCCCCCCCCCC		23663014
707	Phosphorylation	PTLPGTDSLPCSPPV CCCCCCCCCCCCCCC		23663014
711	Phosphorylation	GTDSLPCSPPVSNSY CCCCCCCCCCCCCCC		25159151
715	Phosphorylation	LPCSPPVSNSYTQAD CCCCCCCCCCCCCCC		23663014
717	Phosphorylation	CSPPVSNSYTQADPM CCCCCCCCCCCCCCC		23663014
718	Phosphorylation	SPPVSNSYTQADPMA CCCCCCCCCCCCCCC		23663014
719	Phosphorylation	PPVSNSYTQADPMAP CCCCCCCCCCCCCCC		23663014
728	Phosphorylation	ADPMAPRTPHPSPAH CCCCCCCCCCCCCCC		25849741
732	Phosphorylation	APRTPHPSPAHSSRK CCCCCCCCCCCCCCC		25159151
736	Phosphorylation	PHPSPAHSSRKPLTS CCCCCCCCCCCCCCC		20873877
737	Phosphorylation	HPSPAHSSRKPLTSP CCCCCCCCCCCCCCC		20873877
759	Phosphorylation	TVQSLSPTPSPPTPA CCHHCCCCCCCCCCC		27251275
761	Phosphorylation	QSLSPTPSPPTPAPQ HHCCCCCCCCCCCCC		27251275
764	Phosphorylation	SPTPSPPTPAPQHSD CCCCCCCCCCCCCCH		27251275
770	Phosphorylation	PTPAPQHSDLCLAMA CCCCCCCCHHHHHHH		27251275
841	Phosphorylation	GLTRSRASSLSITVE CCCHHHHHHCEEEHH		24275569
842	Phosphorylation	LTRSRASSLSITVEH CCHHHHHHCEEEHHH		24275569
844	Phosphorylation	RSRASSLSITVEHAL HHHHHHCEEEHHHHH		24275569
874	Phosphorylation	VPGDRPPSSPEAGAE CCCCCCCCCCCCCCC		-
875	Phosphorylation	PGDRPPSSPEAGAED CCCCCCCCCCCCCCC		-
916	Ubiquitination	HCSRLLLKLGTFGPL HHHHHHHHHCCCCCC		-
1005	Phosphorylation	NQYGARLSLRQPGLA HHHCCCCEECCCCHH		23532336
1027	Ubiquitination	LEDALGQKLPRRPQP HHHHHCCCCCCCCCC		-
1084	Ubiquitination	DDQAVVLKALRLAPE CHHHHHHHHHHHCCC		-
1103	Phosphorylation	RDGLRALSSLLVHGN HHHHHHHHHHEECCC		20873877
1104	Phosphorylation	DGLRALSSLLVHGNN HHHHHHHHHEECCCC		20873877
1118	Phosphorylation	NKVMAAVSTQLRSLS CHHHHHHHHHHHHHC		24043423
1119	Phosphorylation	KVMAAVSTQLRSLSL HHHHHHHHHHHHHCC		24043423
1123	Phosphorylation	AVSTQLRSLSLGPTF HHHHHHHHHCCCHHH		23403867
1125	Phosphorylation	STQLRSLSLGPTFRE HHHHHHHCCCHHHHH		23403867
1129	Phosphorylation	RSLSLGPTFRERALL HHHCCCHHHHHHHHH		23403867
1205	Phosphorylation	AHRRLEESLDALPRI HHHHHHHHHHHHCHH		29214152
1217	Phosphorylation	PRIFGPGSMASTAF- CHHHCCCCHHCCCC-		28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTBL_HUMAN	ACTBL2	physical	22863883
DP13B_HUMAN	APPL2	physical	22863883
MYO7A_HUMAN	MYO7A	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.