dbPTM

PRR11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRR11_HUMAN
UniProt AC	Q96HE9
Protein Name	Proline-rich protein 11
Gene Name	PRR11
Organism	Homo sapiens (Human).
Sequence Length	360
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Plays a critical role in cell cycle progression..
Protein Sequence	MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNCITQSLEVLKDTIFPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQPASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTLKPNSKVLSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENMETGTGLTPVMTQALRRKFQLAHPRSPTPTLPLSTSSFDEQN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	HFQSKLITPPPPPPS HHHCCCCCCCCCCCC	39.93	30266825
40	Phosphorylation	TPPPPPPSPERVGIS CCCCCCCCCCCCCCE	45.20	29255136
47	Phosphorylation	SPERVGISSIDISQS CCCCCCCEEEEHHHC	18.47	28450419
48	Phosphorylation	PERVGISSIDISQSR CCCCCCEEEEHHHCC	23.51	28450419
52	Phosphorylation	GISSIDISQSRSWLT CCEEEEHHHCCCCHH	20.53	21815630
54	Phosphorylation	SSIDISQSRSWLTSS EEEEHHHCCCCHHHC	22.84	28450419
116	Ubiquitination	HRELYSVKQQFCILE HHHHHCHHHHHHHHH	32.23	-
125	Ubiquitination	QFCILESKLCKLQEA HHHHHHHHHHHHHHH	48.83	-
128	Ubiquitination	ILESKLCKLQEALKT HHHHHHHHHHHHHHH	64.74	-
139	Phosphorylation	ALKTISESSSCPSCG HHHHHHHHCCCCCCC	22.29	30576142
140	Phosphorylation	LKTISESSSCPSCGQ HHHHHHHCCCCCCCC	31.72	30576142
141	Phosphorylation	KTISESSSCPSCGQT HHHHHHCCCCCCCCC	39.05	30576142
165	Phosphorylation	VPACVLITPGDSKAV CCEEEEECCCCCCCC	19.63	30266825
169	Phosphorylation	VLITPGDSKAVLPPT EEECCCCCCCCCCCC	28.56	30266825
209	Phosphorylation	PVLLRKPSLAKALQA CCHHCCHHHHHHHHC	43.95	-
212	Methylation	LRKPSLAKALQAGPL HCCHHHHHHHHCCCC	55.73	23644510
220	Ubiquitination	ALQAGPLKKDGPMQI HHHCCCCCCCCCCEE	52.53	-
220	Methylation	ALQAGPLKKDGPMQI HHHCCCCCCCCCCEE	52.53	23644510
221	Ubiquitination	LQAGPLKKDGPMQIT HHCCCCCCCCCCEEE	75.50	-
240	Phosphorylation	LTVKLKKTQSLDEKR EEEEEEECCCHHHHH	23.08	28102081
242	Phosphorylation	VKLKKTQSLDEKRKL EEEEECCCHHHHHHC	42.91	24719451
252	Phosphorylation	EKRKLIPSPKARNPL HHHHCCCCCCCCCCC	31.85	30266825
254	Ubiquitination	RKLIPSPKARNPLVT HHCCCCCCCCCCCEE	65.40	-
261	Phosphorylation	KARNPLVTVSDLQHV CCCCCCEEHHHCCCE	23.21	20068231
269	Phosphorylation	VSDLQHVTLKPNSKV HHHCCCEECCCCCCC	27.26	20068231
282	Phosphorylation	KVLSTRVTNVLITPG CCEEEEEEEEEECCC	19.13	30266825
287	Phosphorylation	RVTNVLITPGKSQMD EEEEEEECCCCCHHH	23.10	30266825
290	Acetylation	NVLITPGKSQMDLRK EEEECCCCCHHHHHH	38.42	22424773
290	Ubiquitination	NVLITPGKSQMDLRK EEEECCCCCHHHHHH	38.42	-
291	Phosphorylation	VLITPGKSQMDLRKL EEECCCCCHHHHHHH	36.33	29978859
307	Phosphorylation	RKVDVERSPGGTPLT HHCCCCCCCCCCCCC	17.87	30266825
311	Phosphorylation	VERSPGGTPLTNKEN CCCCCCCCCCCCHHH	22.50	30266825
314	Phosphorylation	SPGGTPLTNKENMET CCCCCCCCCHHHCCC	45.51	21955146
316	Ubiquitination	GGTPLTNKENMETGT CCCCCCCHHHCCCCC	45.27	21906983
321	Phosphorylation	TNKENMETGTGLTPV CCHHHCCCCCCCHHH	29.31	29255136
323	Phosphorylation	KENMETGTGLTPVMT HHHCCCCCCCHHHHH	36.12	29255136
326	Phosphorylation	METGTGLTPVMTQAL CCCCCCCHHHHHHHH	18.38	29255136
330	Phosphorylation	TGLTPVMTQALRRKF CCCHHHHHHHHHHHC	15.78	29255136
336	Ubiquitination	MTQALRRKFQLAHPR HHHHHHHHCCCCCCC	30.91	-
344	Phosphorylation	FQLAHPRSPTPTLPL CCCCCCCCCCCCCCC	37.26	30266825
346	Phosphorylation	LAHPRSPTPTLPLST CCCCCCCCCCCCCCC	30.10	30266825
348	Phosphorylation	HPRSPTPTLPLSTSS CCCCCCCCCCCCCCC	43.41	30266825
352	Phosphorylation	PTPTLPLSTSSFDEQ CCCCCCCCCCCCCCC	25.05	21712546
353	Phosphorylation	TPTLPLSTSSFDEQN CCCCCCCCCCCCCCC	35.75	21712546
354	Phosphorylation	PTLPLSTSSFDEQN- CCCCCCCCCCCCCC-	26.15	25159151
355	Phosphorylation	TLPLSTSSFDEQN-- CCCCCCCCCCCCC--	36.48	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRR11_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRR11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRR11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NIP7_HUMAN	NIP7	physical	26186194
KNOP1_HUMAN	KNOP1	physical	26186194
RBM28_HUMAN	RBM28	physical	26186194
SF3B1_HUMAN	SF3B1	physical	26186194
POP1_HUMAN	POP1	physical	26186194
DDX24_HUMAN	DDX24	physical	26186194
SPB1_HUMAN	FTSJ3	physical	26186194
SF3B2_HUMAN	SF3B2	physical	26186194
ZN668_HUMAN	ZNF668	physical	26186194
RL3_HUMAN	RPL3	physical	26186194
RENT1_HUMAN	UPF1	physical	26186194
ZN512_HUMAN	ZNF512	physical	26186194
RL10A_HUMAN	RPL10A	physical	26186194
DKC1_HUMAN	DKC1	physical	26186194
PABP4_HUMAN	PABPC4	physical	26186194
DHX30_HUMAN	DHX30	physical	26186194
ELAV2_HUMAN	ELAVL2	physical	26186194
DDX27_HUMAN	DDX27	physical	26186194
H11_HUMAN	HIST1H1A	physical	26186194
GLYR1_HUMAN	GLYR1	physical	26186194
DHSO_HUMAN	SORD	physical	26186194
HP1B3_HUMAN	HP1BP3	physical	26186194
REXO4_HUMAN	REXO4	physical	26186194
DDX31_HUMAN	DDX31	physical	26186194
MBB1A_HUMAN	MYBBP1A	physical	26186194
NOP16_HUMAN	NOP16	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
RS3A_HUMAN	RPS3A	physical	26186194
KRI1_HUMAN	KRI1	physical	26186194
NSD2_HUMAN	WHSC1	physical	26186194
CG050_HUMAN	C7orf50	physical	26186194
ZCRB1_HUMAN	ZCRB1	physical	26186194
EBP2_HUMAN	EBNA1BP2	physical	26186194
UTP23_HUMAN	UTP23	physical	26186194
ZCHC3_HUMAN	ZCCHC3	physical	26186194
RRP12_HUMAN	RRP12	physical	26186194
RSBN1_HUMAN	RSBN1	physical	26186194
TTF1_HUMAN	TTF1	physical	26186194
SURF6_HUMAN	SURF6	physical	26186194
LARP1_HUMAN	LARP1	physical	26186194
LYAR_HUMAN	LYAR	physical	26186194
RRP8_HUMAN	RRP8	physical	26186194
STAU2_HUMAN	STAU2	physical	26186194
STAU1_HUMAN	STAU1	physical	26186194
CTCF_HUMAN	CTCF	physical	26186194
NVL_HUMAN	NVL	physical	26186194
NOP53_HUMAN	GLTSCR2	physical	26186194
LLPH_HUMAN	LLPH	physical	26186194
RS15_HUMAN	RPS15	physical	26186194
CCD86_HUMAN	CCDC86	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
LN28B_HUMAN	LIN28B	physical	26186194
NOC4L_HUMAN	NOC4L	physical	26186194
NOC3L_HUMAN	NOC3L	physical	26186194
BRX1_HUMAN	BRIX1	physical	26186194
NOP2_HUMAN	NOP2	physical	26186194
RLP24_HUMAN	RSL24D1	physical	26186194
TSR1_HUMAN	TSR1	physical	26186194
MOV10_HUMAN	MOV10	physical	26186194
PWP1_HUMAN	PWP1	physical	26186194
RRS1_HUMAN	RRS1	physical	26186194
KRR1_HUMAN	KRR1	physical	26186194
RL15_HUMAN	RPL15	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
PK1IP_HUMAN	PAK1IP1	physical	26186194
RL23A_HUMAN	RPL23A	physical	26186194
NOG2_HUMAN	GNL2	physical	26186194
RS13_HUMAN	RPS13	physical	26186194
ZBT24_HUMAN	ZBTB24	physical	26186194
ZN771_HUMAN	ZNF771	physical	26186194
ZBT11_HUMAN	ZBTB11	physical	26186194
RL13A_HUMAN	RPL13A	physical	26186194
PRD15_HUMAN	PRDM15	physical	26186194
RL7L_HUMAN	RPL7L1	physical	26186194
RPF2_HUMAN	RPF2	physical	26186194
ZN800_HUMAN	ZNF800	physical	26186194
PESC_HUMAN	PES1	physical	26186194
CASC3_HUMAN	CASC3	physical	26186194
PURA_HUMAN	PURA	physical	26186194
NSA2_HUMAN	NSA2	physical	26186194
ZNF22_HUMAN	ZNF22	physical	26186194
NOL12_HUMAN	NOL12	physical	26186194
ZN189_HUMAN	ZNF189	physical	26186194
RM38_HUMAN	MRPL38	physical	26186194
ZN689_HUMAN	ZNF689	physical	26186194
DUS11_HUMAN	DUSP11	physical	26186194
H11_HUMAN	HIST1H1A	physical	28514442
ZN800_HUMAN	ZNF800	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
ZCRB1_HUMAN	ZCRB1	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
RRP12_HUMAN	RRP12	physical	28514442
ZN689_HUMAN	ZNF689	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
TTF1_HUMAN	TTF1	physical	28514442
DHSO_HUMAN	SORD	physical	28514442
PRD15_HUMAN	PRDM15	physical	28514442
ZBT24_HUMAN	ZBTB24	physical	28514442
ZN668_HUMAN	ZNF668	physical	28514442
SF3B2_HUMAN	SF3B2	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
RLP24_HUMAN	RSL24D1	physical	28514442
NVL_HUMAN	NVL	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
ZN189_HUMAN	ZNF189	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
DUS11_HUMAN	DUSP11	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
POP1_HUMAN	POP1	physical	28514442
UTP23_HUMAN	UTP23	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
RL7L_HUMAN	RPL7L1	physical	28514442
EBP2_HUMAN	EBNA1BP2	physical	28514442
ZN771_HUMAN	ZNF771	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
PK1IP_HUMAN	PAK1IP1	physical	28514442
CTCF_HUMAN	CTCF	physical	28514442
RS13_HUMAN	RPS13	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442
NOC4L_HUMAN	NOC4L	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
BOP1_HUMAN	BOP1	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRR11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-33; SER-40; THR-287;SER-344; THR-346 AND THR-348, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307 AND THR-314, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND MASSSPECTROMETRY.	17081983 [Abstract]