SOCS5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS5_HUMAN
• UniProt AC: O75159
• Protein Name: Suppressor of cytokine signaling 5
• Gene Name: SOCS5
• Organism: Homo sapiens (Human).
• Sequence Length: 536
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling..
• Protein Sequence: MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Ubiquitination	RCLSVKEKNISIGDS CEEEEEEECCCCCCC	54.59	29967540
51	Phosphorylation	NISIGDSTPQQQSSP CCCCCCCCCCCCCCC	29.83	-
56	Phosphorylation	DSTPQQQSSPLRENI CCCCCCCCCCHHHHH	29.59	25850435
57	Phosphorylation	STPQQQSSPLRENIA CCCCCCCCCHHHHHH	24.50	25850435
70	Phosphorylation	IALQLGLSPSKNSSR HHHHCCCCCCCCCCC	25.90	24719451
72	Phosphorylation	LQLGLSPSKNSSRRN HHCCCCCCCCCCCCC	40.88	30266825
156	Phosphorylation	LQRRERRYGVSSVHD HHHHHHHHCCCCCCC	28.27	-
159	Phosphorylation	RERRYGVSSVHDMDS HHHHHCCCCCCCCCC	23.45	-
160	Phosphorylation	ERRYGVSSVHDMDSV HHHHCCCCCCCCCCC	22.51	24719451
171	Phosphorylation	MDSVSSRTVGSRSLR CCCCCCCCCCCHHHH	31.03	-
174	Phosphorylation	VSSRTVGSRSLRQRL CCCCCCCCHHHHHHH	17.85	-
184	Phosphorylation	LRQRLQDTVGLCFPM HHHHHHHHHHHCCCC	11.96	23403867
198	Phosphorylation	MRTYSKQSKPLFSNK CCCCCCCCCCCCCCC	39.72	24719451
211	Phosphorylation	NKRKIHLSELMLEKC CCCCEEHHHHHHHCC	17.96	27251275
308	Phosphorylation	PKLAPGMTEISGDSS CCCCCCCEECCCCCC	35.76	22210691
315	Phosphorylation	TEISGDSSAIPQANC EECCCCCCCCCCCCC	34.65	22210691
344	Phosphorylation	RQKQRQISGDSHTHV HHHHHHHCCCCCCCC	28.36	29449344
347	Phosphorylation	QRQISGDSHTHVSRQ HHHHCCCCCCCCCCC	33.54	29449344
349	Phosphorylation	QISGDSHTHVSRQGA HHCCCCCCCCCCCCC	28.11	29449344
416	Phosphorylation	AQEDYLFSVSFRRYN CCCCEEEEEEEHHCC	17.79	26699800
418	Phosphorylation	EDYLFSVSFRRYNRS CCEEEEEEEHHCCCC	16.31	26699800
438	Phosphorylation	EQWNHNFSFDAHDPC HHCCCCCCCCCCCCE	27.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LFG3_HUMAN	TMBIM1	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.