NOL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOL4_HUMAN
• UniProt AC: O94818
• Protein Name: Nucleolar protein 4
• Gene Name: NOL4
• Organism: Homo sapiens (Human).
• Sequence Length: 638
• Subcellular Localization: Nucleus, nucleolus .
• Protein Sequence: MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSKGFQLGQPDEVRGGGGGAKQVLYVPVKTTDGVGVDEKLSLRRVAVVEDFFDIIYSMHVETGPNGEQIRKHAGQKRTYKAISESYAFLPREAVTRFLMSCSECQKRMHLNPDGTDHKDNGKPPTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLSSNLEERMQSPQNLHGQQDDDSAAESFNGNETLGHSSIASGGTHSREMGDSNSDGKTGLEQDEQPLNLSDSPLSAQLTSEYRIDDHNSNGKNKYKNLLISDLKMEREARENGSKSPAHSYSSYDSGKNESVDRGAEDLSLNRGDEDEDDHEDHDDSEKVNETDGVEAERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKRIRTYLKSCRRMKRSGFEMSRPIPSHLTSAVAESILASACESESRNAAKRMRLERQQDESAPADKQCKPEATQATYSTSAVPGSQDVLYINGNGTYSYHSYRGLGGGLLNLNDASSSGPTDLSMKRQLATSSGSSSSSNSRPQLSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	FQDWCLRTYGDSGKT HHHHHHHHHCCCCCE	20.93	-
19	Phosphorylation	QDWCLRTYGDSGKTK HHHHHHHHCCCCCEE	16.70	-
33	Phosphorylation	KTVTRKKYERIVQLL EEEEHHHHHHHHHHH	17.30	-
43	Phosphorylation	IVQLLNGSESSSTDN HHHHHCCCCCCCCCC	32.98	26471730
45	Phosphorylation	QLLNGSESSSTDNAK HHHCCCCCCCCCCCE	31.14	26471730
46	Phosphorylation	LLNGSESSSTDNAKF HHCCCCCCCCCCCEE	32.95	26471730
47	Phosphorylation	LNGSESSSTDNAKFK HCCCCCCCCCCCEEE	49.40	26471730
48	Phosphorylation	NGSESSSTDNAKFKF CCCCCCCCCCCEEEE	34.91	26471730
82	Phosphorylation	GGAKQVLYVPVKTTD CCCCEEEEEEEEECC	12.12	26437602
98	Phosphorylation	VGVDEKLSLRRVAVV CCCCCCCCCCEEEEH	30.78	24719451
133	Acetylation	IRKHAGQKRTYKAIS HHHHCCCCCHHHHHH	45.87	18586501
172	Phosphorylation	MHLNPDGTDHKDNGK HCCCCCCCCCCCCCC	42.16	30622161
216	Phosphorylation	SQQDEDESSIESDEF CCCCCCHHHCCCCCC	49.27	22468782
217	Phosphorylation	QQDEDESSIESDEFD CCCCCHHHCCCCCCC	28.47	25921289
220	Phosphorylation	EDESSIESDEFDMSD CCHHHCCCCCCCCCC	40.55	25921289
232	Phosphorylation	MSDSTRMSAVNSDLS CCCCHHHHHHCCHHH	26.27	27732954
236	Phosphorylation	TRMSAVNSDLSSNLE HHHHHHCCHHHHCHH	33.07	27732954
239	Phosphorylation	SAVNSDLSSNLEERM HHHCCHHHHCHHHHH	23.36	22468782
240	Phosphorylation	AVNSDLSSNLEERMQ HHCCHHHHCHHHHHH	53.37	27732954
248	Phosphorylation	NLEERMQSPQNLHGQ CHHHHHHCCCCCCCC	21.07	28348404
260	Phosphorylation	HGQQDDDSAAESFNG CCCCCCCHHHHHCCC	36.05	25921289
264	Phosphorylation	DDDSAAESFNGNETL CCCHHHHHCCCCCCC	21.20	25921289
295	Phosphorylation	DSNSDGKTGLEQDEQ CCCCCCCCCCCCCCC	53.15	27732954
307	Phosphorylation	DEQPLNLSDSPLSAQ CCCCCCCCCCCCHHH	34.66	27732954
309	Phosphorylation	QPLNLSDSPLSAQLT CCCCCCCCCCHHHHC	25.10	27732954
312	Phosphorylation	NLSDSPLSAQLTSEY CCCCCCCHHHHCCEE	19.83	27732954
316	Phosphorylation	SPLSAQLTSEYRIDD CCCHHHHCCEEECCC	13.87	27732954
317	Phosphorylation	PLSAQLTSEYRIDDH CCHHHHCCEEECCCC	41.02	27732954
319	Phosphorylation	SAQLTSEYRIDDHNS HHHHCCEEECCCCCC	16.79	27732954
351	Phosphorylation	REARENGSKSPAHSY HHHHHCCCCCCCCCC	41.35	-
353	Phosphorylation	ARENGSKSPAHSYSS HHHCCCCCCCCCCCC	29.08	22496350
357	Phosphorylation	GSKSPAHSYSSYDSG CCCCCCCCCCCCCCC	28.90	27732954
358	Phosphorylation	SKSPAHSYSSYDSGK CCCCCCCCCCCCCCC	7.56	27732954
359	Phosphorylation	KSPAHSYSSYDSGKN CCCCCCCCCCCCCCC	25.99	27732954
360	Phosphorylation	SPAHSYSSYDSGKNE CCCCCCCCCCCCCCC	25.40	27732954
361	Phosphorylation	PAHSYSSYDSGKNES CCCCCCCCCCCCCCC	14.26	27732954
363	Phosphorylation	HSYSSYDSGKNESVD CCCCCCCCCCCCCCC	43.35	27732954
368	Phosphorylation	YDSGKNESVDRGAED CCCCCCCCCCCCHHH	38.42	27732954
394	Phosphorylation	DHEDHDDSEKVNETD CCCCCCCHHHCCCCC	45.43	30576142
443	Phosphorylation	KIQAIIDSCRRQFPE HHHHHHHHHHHHCHH	10.10	30108239
451	Phosphorylation	CRRQFPEYQERARKR HHHHCHHHHHHHHHH	18.86	24043423
461	Phosphorylation	RARKRIRTYLKSCRR HHHHHHHHHHHHHHH	30.73	26074081
462	Phosphorylation	ARKRIRTYLKSCRRM HHHHHHHHHHHHHHH	11.41	26074081
465	Phosphorylation	RIRTYLKSCRRMKRS HHHHHHHHHHHHHHC	15.40	26074081
602	Phosphorylation	SNSRPQLSPTEINAV CCCCCCCCHHHHHHH	25.24	27732954
604	Phosphorylation	SRPQLSPTEINAVRQ CCCCCCHHHHHHHHH	46.23	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNPC5_HUMAN	SNAPC5	physical	16189514
SNPC5_HUMAN	SNAPC5	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.