SNPC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNPC5_HUMAN
• UniProt AC: O75971
• Protein Name: snRNA-activating protein complex subunit 5
• Gene Name: SNAPC5
• Organism: Homo sapiens (Human).
• Sequence Length: 98
• Subcellular Localization: Nucleus.
• Protein Description: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box..
• Protein Sequence: MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHDMLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Methylation	EETLLRLKAALHDQL HHHHHHHHHHHHHHH	25.77	115980815
19	Ubiquitination	EETLLRLKAALHDQL HHHHHHHHHHHHHHH	25.77	-
41	Phosphorylation	LALQSMISSRRGDEM HHHHHHHHCCCCHHH	14.78	-
42	Phosphorylation	ALQSMISSRRGDEML HHHHHHHCCCCHHHH	18.31	-
58	Phosphorylation	SHTVPEQSHDMLVHV CCCCCCCCCCEEEEE	21.57	-
80	Phosphorylation	QTTLELSTKSHVTEE CHHHHHHCCCCCCHH	49.55	-
85	Phosphorylation	LSTKSHVTEEEEEEE HHCCCCCCHHHHHHH	32.05	23927012
96	Phosphorylation	EEEEEEESDS----- HHHHHHHCCC-----	46.57	26503892
98	Phosphorylation	EEEEESDS------- HHHHHCCC-------	51.94	30278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNPC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNPC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNPC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BATF_HUMAN	BATF	physical	16189514
BRCC3_HUMAN	BRCC3	physical	16189514
SSA27_HUMAN	SSSCA1	physical	25416956
NUP62_HUMAN	NUP62	physical	25416956
CYH4_HUMAN	CYTH4	physical	25416956
NDEL1_HUMAN	NDEL1	physical	25416956
AMOT_HUMAN	AMOT	physical	25416956
NUD10_HUMAN	NUDT10	physical	25416956
NMI_HUMAN	NMI	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-85 AND SER-96, AND MASSSPECTROMETRY.
PubMed: 18669648