dbPTM

ZN217_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN217_HUMAN
UniProt AC	O75362
Protein Name	Zinc finger protein 217
Gene Name	ZNF217
Organism	Homo sapiens (Human).
Sequence Length	1048
Subcellular Localization	Nucleus .
Protein Description	Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'..
Protein Sequence	MQSKVTGNMPTQSLLMYMDGPEVIGSSLGSPMEMEDALSMKGTAVVPFRATQEKNVIQIEGYMPLDCMFCSQTFTHSEDLNKHVLMQHRPTLCEPAVLRVEAEYLSPLDKSQVRTEPPKEKNCKENEFSCEVCGQTFRVAFDVEIHMRTHKDSFTYGCNMCGRRFKEPWFLKNHMRTHNGKSGARSKLQQGLESSPATINEVVQVHAAESISSPYKICMVCGFLFPNKESLIEHRKVHTKKTAFGTSSAQTDSPQGGMPSSREDFLQLFNLRPKSHPETGKKPVRCIPQLDPFTTFQAWQLATKGKVAICQEVKESGQEGSTDNDDSSSEKELGETNKGSCAGLSQEKEKCKHSHGEAPSVDADPKLPSSKEKPTHCSECGKAFRTYHQLVLHSRVHKKDRRAGAESPTMSVDGRQPGTCSPDLAAPLDENGAVDRGEGGSEDGSEDGLPEGIHLDKNDDGGKIKHLTSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFCEYAAAQKTSLRYHLERHHKEKQTDVAAEVKNDGKNQDTEDALLTADSAQTKNLKRFFDGAKDVTGSPPAKQLKEMPSVFQNVLGSAVLSPAHKDTQDFHKNAADDSADKVNKNPTPAYLDLLKKRSAVETQANNLICRTKADVTPPPDGSTTHNLEVSPKEKQTETAADCRYRPSVDCHEKPLNLSVGALHNCPAISLSKSLIPSITCPFCTFKTFYPEVLMMHQRLEHKYNPDVHKNCRNKSLLRSRRTGCPPALLGKDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAPSNLKSHRPQQNVGVQGAATRQQQSEMFPKTSVSPAPDKTKRPETKLKPLPVAPSQPTLGSSNINGSIDYPAKNDSPWAPPGRDYFCNRSASNTAAEFGEPLPKRLKSSVVALDVDQPGANYRRGYDLPKYHMVRGITSLLPQDCVYPSQALPPKPRFLSSSEVDSPNVLTVQKPYGGSGPLYTCVPAGSPASSSTLEGKRPVSYQHLSNSMAQKRNYENFIGNAHYRPNDKKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MQSKVTGNMPTQS --CCCCCCCCCCCCC	26.95	24043423
11	Phosphorylation	KVTGNMPTQSLLMYM CCCCCCCCCCEEEEC	21.74	24043423
13	Phosphorylation	TGNMPTQSLLMYMDG CCCCCCCCEEEECCC	26.42	24043423
17	Phosphorylation	PTQSLLMYMDGPEVI CCCCEEEECCCCHHC	7.63	24043423
26	Phosphorylation	DGPEVIGSSLGSPME CCCHHCCCCCCCCCC	15.97	24043423
27	Phosphorylation	GPEVIGSSLGSPMEM CCHHCCCCCCCCCCH	31.38	24043423
30	Phosphorylation	VIGSSLGSPMEMEDA HCCCCCCCCCCHHHH	26.77	24043423
39	Phosphorylation	MEMEDALSMKGTAVV CCHHHHHHCCCEEEE	21.84	24043423
51	Phosphorylation	AVVPFRATQEKNVIQ EEEEECCCCCCCEEE	32.76	-
104	Phosphorylation	VLRVEAEYLSPLDKS EHEEEEEECCCCCHH	21.37	28796482
106	Phosphorylation	RVEAEYLSPLDKSQV EEEEEECCCCCHHHC	23.63	25159151
111	Phosphorylation	YLSPLDKSQVRTEPP ECCCCCHHHCCCCCC	33.31	21712546
115	Phosphorylation	LDKSQVRTEPPKEKN CCHHHCCCCCCCCCC	54.72	22468782
194	Phosphorylation	KLQQGLESSPATINE HHHHHHHCCCCCHHH	46.82	25627689
195	Phosphorylation	LQQGLESSPATINEV HHHHHHCCCCCHHHH	14.80	25627689
242	Phosphorylation	RKVHTKKTAFGTSSA HCCCCCCCCCCCCCC	28.86	-
246	Phosphorylation	TKKTAFGTSSAQTDS CCCCCCCCCCCCCCC	17.04	30576142
247	Phosphorylation	KKTAFGTSSAQTDSP CCCCCCCCCCCCCCC	24.85	23911959
248	Phosphorylation	KTAFGTSSAQTDSPQ CCCCCCCCCCCCCCC	25.00	23911959
251	Phosphorylation	FGTSSAQTDSPQGGM CCCCCCCCCCCCCCC	37.85	28985074
253	Phosphorylation	TSSAQTDSPQGGMPS CCCCCCCCCCCCCCC	23.63	28985074
260	Phosphorylation	SPQGGMPSSREDFLQ CCCCCCCCCHHHHHH	32.89	28102081
261	Phosphorylation	PQGGMPSSREDFLQL CCCCCCCCHHHHHHH	33.54	23911959
316	Phosphorylation	ICQEVKESGQEGSTD EEECHHHHCCCCCCC	39.81	23663014
321	Phosphorylation	KESGQEGSTDNDDSS HHHCCCCCCCCCCCH	31.66	23663014
322	Phosphorylation	ESGQEGSTDNDDSSS HHCCCCCCCCCCCHH	50.07	23663014
327	Phosphorylation	GSTDNDDSSSEKELG CCCCCCCCHHHHHHC	38.33	25849741
328	Phosphorylation	STDNDDSSSEKELGE CCCCCCCHHHHHHCC	49.89	23663014
329	Phosphorylation	TDNDDSSSEKELGET CCCCCCHHHHHHCCC	57.55	23663014
336	Phosphorylation	SEKELGETNKGSCAG HHHHHCCCCCCCCCC	40.19	23663014
345	Phosphorylation	KGSCAGLSQEKEKCK CCCCCCCHHHHHHHC	35.06	25159151
354	Phosphorylation	EKEKCKHSHGEAPSV HHHHHCCCCCCCCCC	20.77	20068231
360	Phosphorylation	HSHGEAPSVDADPKL CCCCCCCCCCCCCCC	39.41	20068231
369	Phosphorylation	DADPKLPSSKEKPTH CCCCCCCCCCCCCCC	65.56	20068231
370	Phosphorylation	ADPKLPSSKEKPTHC CCCCCCCCCCCCCCH	42.78	20068231
407	Phosphorylation	DRRAGAESPTMSVDG HHCCCCCCCCCCCCC	25.74	19664994
409	Phosphorylation	RAGAESPTMSVDGRQ CCCCCCCCCCCCCCC	31.21	30266825
411	Phosphorylation	GAESPTMSVDGRQPG CCCCCCCCCCCCCCC	21.38	23401153
419	Phosphorylation	VDGRQPGTCSPDLAA CCCCCCCCCCCCCCC	19.25	25850435
421	Phosphorylation	GRQPGTCSPDLAAPL CCCCCCCCCCCCCCC	22.68	26657352
441	Phosphorylation	VDRGEGGSEDGSEDG CCCCCCCCCCCCCCC	43.29	29255136
445	Phosphorylation	EGGSEDGSEDGLPEG CCCCCCCCCCCCCCC	44.85	29255136
492	Phosphorylation	YLNIHLRTHTGEKPY EEEEEEEECCCCCCE	30.10	28348404
494	Phosphorylation	NIHLRTHTGEKPYKC EEEEEECCCCCCEEC	46.56	29214152
497	Ubiquitination	LRTHTGEKPYKCEFC EEECCCCCCEECCCC	55.80	-
527	Phosphorylation	RHHKEKQTDVAAEVK HHHHCCCCCHHHHHC	43.43	-
568	Phosphorylation	FDGAKDVTGSPPAKQ HCCCCCCCCCCCHHH	41.92	30266825
570	Phosphorylation	GAKDVTGSPPAKQLK CCCCCCCCCCHHHHH	20.53	23401153
581	Phosphorylation	KQLKEMPSVFQNVLG HHHHHCCHHHHHHHH	33.96	20068231
589	Phosphorylation	VFQNVLGSAVLSPAH HHHHHHHHHHCCCCC	15.84	30266825
593	Phosphorylation	VLGSAVLSPAHKDTQ HHHHHHCCCCCCCHH	17.28	30266825
619	Phosphorylation	DKVNKNPTPAYLDLL HHHCCCCCHHHHHHH	29.91	28555341
627	Ubiquitination	PAYLDLLKKRSAVET HHHHHHHHHHCCHHH	54.13	-
630	Phosphorylation	LDLLKKRSAVETQAN HHHHHHHCCHHHHHC	45.61	28555341
643	Phosphorylation	ANNLICRTKADVTPP HCCEEECCCCCCCCC	26.60	28450419
648	Phosphorylation	CRTKADVTPPPDGST ECCCCCCCCCCCCCC	30.53	23401153
654	Phosphorylation	VTPPPDGSTTHNLEV CCCCCCCCCCCCEEE	37.20	29255136
655	Phosphorylation	TPPPDGSTTHNLEVS CCCCCCCCCCCEEEC	37.29	29255136
656	Phosphorylation	PPPDGSTTHNLEVSP CCCCCCCCCCEEECC	15.51	29255136
662	Phosphorylation	TTHNLEVSPKEKQTE CCCCEEECCCHHCCC	22.37	30266825
676	Phosphorylation	ETAADCRYRPSVDCH CCHHHCCCCCCCCCC	32.96	25311616
679	Phosphorylation	ADCRYRPSVDCHEKP HHCCCCCCCCCCCCC	22.91	25311616
685	Acetylation	PSVDCHEKPLNLSVG CCCCCCCCCCCCCCH	31.01	26051181
690	Phosphorylation	HEKPLNLSVGALHNC CCCCCCCCCHHHHCC	19.89	25311616
701	Phosphorylation	LHNCPAISLSKSLIP HHCCCCHHCCCCCCC	28.79	24719451
705	Phosphorylation	PAISLSKSLIPSITC CCHHCCCCCCCCCCC	28.31	27251275
741	Ubiquitination	KYNPDVHKNCRNKSL HCCCHHHHCCCCHHH	58.55	-
747	Phosphorylation	HKNCRNKSLLRSRRT HHCCCCHHHHHHHCC	35.86	24719451
785	Acetylation	SAFPAQSKSLPSAKG CCCCCCCCCCCCCCC	43.88	18525467
789	Phosphorylation	AQSKSLPSAKGKQSP CCCCCCCCCCCCCCC	48.16	24719451
795	Phosphorylation	PSAKGKQSPPGPGKA CCCCCCCCCCCCCCC	36.23	23401153
805	Phosphorylation	GPGKAPLTSGIDSST CCCCCCCCCCCCCCC	24.69	30108239
806	Phosphorylation	PGKAPLTSGIDSSTL CCCCCCCCCCCCCCC	41.24	26074081
810	Phosphorylation	PLTSGIDSSTLAPSN CCCCCCCCCCCCCCC	24.25	30576142
811	Phosphorylation	LTSGIDSSTLAPSNL CCCCCCCCCCCCCCC	24.56	26074081
812	Phosphorylation	TSGIDSSTLAPSNLK CCCCCCCCCCCCCCC	30.78	30576142
816	Phosphorylation	DSSTLAPSNLKSHRP CCCCCCCCCCCCCCC	49.54	26074081
819	Ubiquitination	TLAPSNLKSHRPQQN CCCCCCCCCCCCCCC	48.76	-
819	Sumoylation	TLAPSNLKSHRPQQN CCCCCCCCCCCCCCC	48.76	28112733
834	Phosphorylation	VGVQGAATRQQQSEM CCCCCCHHHHHHHHH	28.60	-
839	Phosphorylation	AATRQQQSEMFPKTS CHHHHHHHHHCCCCC	27.04	20068231
845	Phosphorylation	QSEMFPKTSVSPAPD HHHHCCCCCCCCCCC	34.30	23403867
846	Phosphorylation	SEMFPKTSVSPAPDK HHHCCCCCCCCCCCC	27.07	26657352
848	Phosphorylation	MFPKTSVSPAPDKTK HCCCCCCCCCCCCCC	18.34	23927012
853	Acetylation	SVSPAPDKTKRPETK CCCCCCCCCCCCCCC	55.69	30593669
854	Phosphorylation	VSPAPDKTKRPETKL CCCCCCCCCCCCCCC	39.40	26074081
869	Phosphorylation	KPLPVAPSQPTLGSS CCCCCCCCCCCCCCC	38.77	-
881	Phosphorylation	GSSNINGSIDYPAKN CCCCCCCCCCCCCCC	14.06	28555341
890	Phosphorylation	DYPAKNDSPWAPPGR CCCCCCCCCCCCCCC	31.56	21815630
904	Phosphorylation	RDYFCNRSASNTAAE CCCCCCCCCCCHHHH	23.27	28450419
906	Phosphorylation	YFCNRSASNTAAEFG CCCCCCCCCHHHHHC	35.64	28450419
908	Phosphorylation	CNRSASNTAAEFGEP CCCCCCCHHHHHCCC	25.42	28450419
918	Ubiquitination	EFGEPLPKRLKSSVV HHCCCCCHHHHCCEE	77.40	-
921	Ubiquitination	EPLPKRLKSSVVALD CCCCHHHHCCEEEEE	44.72	-
974	Phosphorylation	PPKPRFLSSSEVDSP CCCCCCCCCCCCCCC	29.16	30576142
975	Phosphorylation	PKPRFLSSSEVDSPN CCCCCCCCCCCCCCC	32.44	22199227
976	Phosphorylation	KPRFLSSSEVDSPNV CCCCCCCCCCCCCCE	37.96	25850435
980	Phosphorylation	LSSSEVDSPNVLTVQ CCCCCCCCCCEEEEE	24.45	22199227
1004	Phosphorylation	YTCVPAGSPASSSTL EEEEECCCCCCCCCC	21.28	25159151
1007	Phosphorylation	VPAGSPASSSTLEGK EECCCCCCCCCCCCC	28.36	-
1025	Phosphorylation	SYQHLSNSMAQKRNY CHHHHHHHHHHHHCH	16.48	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN217_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN217_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN217_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	19242095
EHMT2_HUMAN	EHMT2	physical	19242095
CTBP1_HUMAN	CTBP1	physical	19242095
RCOR1_HUMAN	RCOR1	physical	19242095
KDM5B_HUMAN	KDM5B	physical	19242095
RCOR1_HUMAN	RCOR1	physical	18625718
KDM1A_HUMAN	KDM1A	physical	18625718
HDAC2_HUMAN	HDAC2	physical	18625718
CTBP1_HUMAN	CTBP1	physical	18625718
RCOR1_HUMAN	RCOR1	physical	17967884
KDM1A_HUMAN	KDM1A	physical	17967884
HDAC2_HUMAN	HDAC2	physical	17967884
CTBP1_HUMAN	CTBP1	physical	17967884
CTBP2_HUMAN	CTBP2	physical	17967884
H31T_HUMAN	HIST3H3	physical	12700765

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN217_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; THR-322; SER-327;THR-648 AND SER-662, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407; SER-570; SER-795AND SER-848, AND MASS SPECTROMETRY.	15302935 [Abstract]