PAR3L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR3L_HUMAN
• UniProt AC: Q8TEW8
• Protein Name: Partitioning defective 3 homolog B
• Gene Name: PARD3B
• Organism: Homo sapiens (Human).
• Sequence Length: 1205
• Subcellular Localization: Endomembrane system. Cell junction. Cell junction, tight junction. Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
• Protein Description: Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions..
• Protein Sequence: MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMTAAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	QLRVGELTQQALQRY CCCHHHHHHHHHHHH	17.84	23403867
74	Acetylation	DVVEDKDKLIAVFEE HHHCCHHHEEEEEEC	47.75	20167786
90	Phosphorylation	EPLHKIESPSGNPAD CCHHCCCCCCCCCCC	28.04	26657352
92	Phosphorylation	LHKIESPSGNPADRQ HHCCCCCCCCCCCCC	61.55	29514088
100	Phosphorylation	GNPADRQSPDAFETE CCCCCCCCCCHHHHH	26.16	26657352
106	Phosphorylation	QSPDAFETEVAAQLA CCCCHHHHHHHHHHH	29.34	29514088
125	Phosphorylation	IGGEIEVTPSALKLG CCCEEEECHHHHHCC	9.95	22199227
127	Phosphorylation	GEIEVTPSALKLGTP CEEEECHHHHHCCCC	36.55	22199227
133	Phosphorylation	PSALKLGTPLLVRRS HHHHHCCCCEEEECC	22.62	30266825
140	Phosphorylation	TPLLVRRSSDPVPGP CCEEEECCCCCCCCC	28.64	25849741
141	Phosphorylation	PLLVRRSSDPVPGPP CEEEECCCCCCCCCC	44.09	26657352
151	Phosphorylation	VPGPPADTQPSASHP CCCCCCCCCCCCCCC	44.48	26699800
154	Phosphorylation	PPADTQPSASHPGGQ CCCCCCCCCCCCCCC	32.36	23312004
156	Phosphorylation	ADTQPSASHPGGQSL CCCCCCCCCCCCCCE	34.25	23312004
162	Phosphorylation	ASHPGGQSLKLVVPD CCCCCCCCEEEECCC	30.65	23312004
190	Phosphorylation	VQTELLTSPRTKDTL HHHHHHCCCCCCCCH	16.62	21815630
193	Phosphorylation	ELLTSPRTKDTLSDM HHHCCCCCCCCHHHC	36.33	-
203	Phosphorylation	TLSDMTRTVEISGEG CHHHCEEEEEECCCC	17.21	-
207	Phosphorylation	MTRTVEISGEGGPLG CEEEEEECCCCCCCE	19.79	-
280	Phosphorylation	VFRQAMKSPSVLLHV HHHHHHCCCCCEEEC	14.88	28842319
330	Phosphorylation	HGKSGLKTANLTGTD CCCCCCCCCCCCCCC	26.31	23186163
334	Phosphorylation	GLKTANLTGTDSPET CCCCCCCCCCCCCCC	37.53	23403867
336	Phosphorylation	KTANLTGTDSPETDA CCCCCCCCCCCCCCC	28.24	23403867
338	Phosphorylation	ANLTGTDSPETDASA CCCCCCCCCCCCCHH	25.19	23403867
341	Phosphorylation	TGTDSPETDASASLQ CCCCCCCCCCHHHHH	40.00	23401153
344	Phosphorylation	DSPETDASASLQQNK CCCCCCCHHHHHCCC	22.62	27251789
346	Phosphorylation	PETDASASLQQNKSP CCCCCHHHHHCCCCC	24.98	28387310
352	Phosphorylation	ASLQQNKSPRVPRLG HHHHCCCCCCCCCCC	26.03	29255136
363	Phosphorylation	PRLGGKPSSPSLSPL CCCCCCCCCCCCCCC	59.37	30266825
364	Phosphorylation	RLGGKPSSPSLSPLM CCCCCCCCCCCCCCC	27.34	30266825
366	Phosphorylation	GGKPSSPSLSPLMGF CCCCCCCCCCCCCCC	43.35	30266825
368	Phosphorylation	KPSSPSLSPLMGFGS CCCCCCCCCCCCCCC	21.96	30266825
375	Phosphorylation	SPLMGFGSNKNAKKI CCCCCCCCCCCCCEE	42.23	23403867
402	Phosphorylation	FTVVTRDSSIHGPGP EEEEECCCCCCCCCC	28.09	28857561
403	Phosphorylation	TVVTRDSSIHGPGPI EEEECCCCCCCCCCE	23.93	28857561
442	Phosphorylation	EVNGRDVTGRTQEEL EECCEECCCCCHHHH	25.82	24719451
445	Phosphorylation	GRDVTGRTQEELVAM CEECCCCCHHHHHHH	41.50	20044836
455	Phosphorylation	ELVAMLRSTKQGETA HHHHHHHHCCCCCEE	35.67	24719451
455 (in isoform 2)	Phosphorylation	-	35.67	24719451
456	Phosphorylation	LVAMLRSTKQGETAS HHHHHHHCCCCCEEE	22.43	20044836
514	Methylation	AGLGVSLKGNKSRET CCCCEEECCCCCCCC	53.59	-
517	Methylation	GVSLKGNKSRETGTD CEEECCCCCCCCCCC	60.60	-
561	Ubiquitination	NGESLLGKSNHEAME CCHHHCCCCHHHHHH	48.32	-
575	Phosphorylation	ETLRRSMSMEGNIRG HHHHHHHHHCCCHHH	18.22	28857561
633	Phosphorylation	SILHPLGTCSPQDKQ CCEECCCCCCHHHHC	19.93	23663014
635	Phosphorylation	LHPLGTCSPQDKQKG EECCCCCCHHHHCCC	25.98	23663014
682	Phosphorylation	SSGVDSAVYFPDQHI CCCCCCEEECCCCCC	6.15	32142685
684	Phosphorylation	GVDSAVYFPDQHINF CCCCEEECCCCCCCC	4.29	32645325
687	Phosphorylation	SAVYFPDQHINFRSV CEEECCCCCCCCEEC	39.33	33259812
693	Phosphorylation	DQHINFRSVTPARQP CCCCCCEECCCCCCC	26.63	28857561
695	Phosphorylation	HINFRSVTPARQPES CCCCEECCCCCCCCC	16.69	28857561
710	Phosphorylation	INLKASKSMDLVPDE CCCCCCCCCCCCCCH	18.29	28355574
710	Ubiquitination	INLKASKSMDLVPDE CCCCCCCCCCCCCCH	18.29	24816145
728	Phosphorylation	HSLAGQKSESPSKDF HHHCCCCCCCCCCCC	35.10	23663014
730	Phosphorylation	LAGQKSESPSKDFGP HCCCCCCCCCCCCCC	41.38	30266825
732	Phosphorylation	GQKSESPSKDFGPTL CCCCCCCCCCCCCCC	54.88	23663014
738	Phosphorylation	PSKDFGPTLGLKKSS CCCCCCCCCCCCCCC	33.56	24702127
742	Ubiquitination	FGPTLGLKKSSSLES CCCCCCCCCCCCHHH	49.13	24816145
744	Phosphorylation	PTLGLKKSSSLESLQ CCCCCCCCCCHHHHH	24.46	30266825
745	Phosphorylation	TLGLKKSSSLESLQT CCCCCCCCCHHHHHH	48.07	30266825
746	Phosphorylation	LGLKKSSSLESLQTA CCCCCCCCHHHHHHH	43.16	29255136
749	Phosphorylation	KKSSSLESLQTAVAE CCCCCHHHHHHHHHH	30.94	30266825
752	Phosphorylation	SSLESLQTAVAEVRK CCHHHHHHHHHHHHH	28.52	30266825
780	Phosphorylation	RGRGCNESFRAAIDK CCCCCCHHHHHHHHC	13.17	30266825
800	Methylation	EEIEADGLSDKSSHS HHHCCCCCCCCCCCC	6.52	-
801	Methylation	EIEADGLSDKSSHSG HHCCCCCCCCCCCCC	48.82	-
801	Phosphorylation	EIEADGLSDKSSHSG HHCCCCCCCCCCCCC	48.82	25159151
805	Phosphorylation	DGLSDKSSHSGQGAL CCCCCCCCCCCCCCC	27.67	22777824
807	Phosphorylation	LSDKSSHSGQGALNC CCCCCCCCCCCCCCC	34.46	22777824
840	Ubiquitination	KVKKTKEKEKKKEKG HHHHHHHHHHHHHHC	76.12	24816145
844	Acetylation	TKEKEKKKEKGKLKV HHHHHHHHHHCCCCH	75.60	71075
847	Ubiquitination	KEKKKEKGKLKVKEK HHHHHHHCCCCHHHH	41.44	24816145
848	Acetylation	EKKKEKGKLKVKEKK HHHHHHCCCCHHHHH	57.09	71071
850	Acetylation	KKEKGKLKVKEKKRK HHHHCCCCHHHHHHH	55.54	71073
852	Acetylation	EKGKLKVKEKKRKEE HHCCCCHHHHHHHHH	63.33	8273297
853	Ubiquitination	KGKLKVKEKKRKEEN HCCCCHHHHHHHHHC	67.79	24816145
854	Acetylation	GKLKVKEKKRKEENE CCCCHHHHHHHHHCC	52.76	71077
855	Ubiquitination	KLKVKEKKRKEENED CCCHHHHHHHHHCCC	70.56	24816145
869	Methylation	DPERKIKKKGFGAML CHHHHHHHHCHHHHH	62.70	23644510
870	Methylation	PERKIKKKGFGAMLR HHHHHHHHCHHHHHH	55.24	23644510
885	Acetylation	FGKKKEDKGGKAEQK CCCCCCCCCCCCCCC	71.32	12433797
887	Ubiquitination	KKKEDKGGKAEQKGT CCCCCCCCCCCCCCC	31.57	24816145
892	Acetylation	KGGKAEQKGTLKHGG CCCCCCCCCCCCCCC	45.42	12433809
897	Ubiquitination	EQKGTLKHGGLREEE CCCCCCCCCCCCHHH	38.37	24816145
909	Ubiquitination	EEELEKMKEERERIG HHHHHHHHHHHHHHH	68.44	24816145
914 (in isoform 5)	Phosphorylation	-	38.57	29507054
917	Ubiquitination	EERERIGAKHQELRE HHHHHHHHHHHHHHH	12.09	24816145
918 (in isoform 5)	Phosphorylation	-	40.38	29507054
921 (in isoform 5)	Phosphorylation	-	49.90	29507054
922 (in isoform 5)	Phosphorylation	-	7.44	29507054
953	Phosphorylation	DDEMDPNYARVNHFR CCCCCCCCCCCCCCC	10.94	-
964	Phosphorylation	NHFREPCTSANVFRS CCCCCCCCCCCCCCC	41.40	29449344
965	Phosphorylation	HFREPCTSANVFRSP CCCCCCCCCCCCCCC	25.27	29449344
971	Phosphorylation	TSANVFRSPSPPRAG CCCCCCCCCCCCCCC	20.47	23927012
973	Phosphorylation	ANVFRSPSPPRAGPF CCCCCCCCCCCCCCC	49.10	23927012
982	Phosphorylation	PRAGPFGYPRDGHPL CCCCCCCCCCCCCCC	8.75	23312004
990	Phosphorylation	PRDGHPLSPERDHLE CCCCCCCCCCHHHHH	29.21	27134283
1000	Phosphorylation	RDHLEGLYAKVNKPY HHHHHHHHHCCCCCC	18.42	21082442
1007	Phosphorylation	YAKVNKPYHPLVPAD HHCCCCCCCCCCCCC	20.06	27642862
1015	Phosphorylation	HPLVPADSGRPTGGS CCCCCCCCCCCCCCC	38.52	28348404
1019	Phosphorylation	PADSGRPTGGSTDRI CCCCCCCCCCCHHHH	53.46	26657352
1022	Phosphorylation	SGRPTGGSTDRIQKL CCCCCCCCHHHHHHH	28.60	28857561
1023	Phosphorylation	GRPTGGSTDRIQKLR CCCCCCCHHHHHHHH	32.35	28348404
1033	Phosphorylation	IQKLRKEYYQARREG HHHHHHHHHHHHHCC	12.15	29496907
1044	Phosphorylation	RREGFPLYEDDEGRA HHCCCCCCCCCCCCC	19.97	28674419
1054	Phosphorylation	DEGRARPSEYDLLWV CCCCCCCCCCCEEEE	43.14	29978859
1056	Phosphorylation	GRARPSEYDLLWVPG CCCCCCCCCEEEECC	19.07	29978859
1082	Phosphorylation	FEGMERQYASLPRGG CCCCHHHHCCCCCCC	12.36	27642862
1084	Phosphorylation	GMERQYASLPRGGPA CCHHHHCCCCCCCCC	33.69	24719451
1087	Methylation	RQYASLPRGGPADPV HHHCCCCCCCCCCHH	68.91	115486413
1096	Phosphorylation	GPADPVDYLPAAPRG CCCCHHHCCCCCCCC	18.15	29978859
1112	Phosphorylation	YKERELPYYPGAHPM CCCCCCCCCCCCCCC	34.61	27642862
1130	Phosphorylation	KGSYPRPTELRVADL CCCCCCCCEEEEECC	49.26	24719451
1162	Phosphorylation	FRQDVPPSPPQHQRM CCCCCCCCCCHHHCC	43.04	30266825
1172	Phosphorylation	QHQRMPAYQETGRPG HHHCCCCCCCCCCCC	10.87	22817900
1181	Methylation	ETGRPGPRGGSPDQY CCCCCCCCCCCCCCC	68.93	16288567
1184	Phosphorylation	RPGPRGGSPDQYPYR CCCCCCCCCCCCCCC	28.29	20363803
1188	Phosphorylation	RGGSPDQYPYRTQDS CCCCCCCCCCCCCCC	15.04	22817900
1190	Phosphorylation	GSPDQYPYRTQDSRQ CCCCCCCCCCCCCCC	22.74	22817900
1191	Dimethylation	SPDQYPYRTQDSRQK CCCCCCCCCCCCCCC	22.77	-
1191	Methylation	SPDQYPYRTQDSRQK CCCCCCCCCCCCCCC	22.77	24380837
1192	Phosphorylation	PDQYPYRTQDSRQKN CCCCCCCCCCCCCCC	30.77	22817900
1195	Phosphorylation	YPYRTQDSRQKNPMT CCCCCCCCCCCCCCC	27.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR3L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR3L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR3L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PAR3L_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1000, AND MASSSPECTROMETRY.
PubMed: 18083107